|
|||||
|
|
| 一氧化氮对约氏疟原虫裂殖子感染力的影响 | |
| 引用本文： | 阎建忠,刘军,邓立军,杨毅梅,刘英杰,杨杰,曹雅明. 一氧化氮对约氏疟原虫裂殖子感染力的影响[J]. 中国公共卫生, 2004, 20(8): 975-976 |
| 作者姓名： | 阎建忠 刘军 邓立军 杨毅梅 刘英杰 杨杰 曹雅明 |
| 作者单位： | 1. 中国医科大学基础医学院,沈阳,110001 2. 大理学院基础医学院寄生虫学教研室 3. 沈阳市和平区中医院 |
| 摘 要： | 目的 探讨一氧化氮(NO)对红内期疟原虫裂殖子感染力的影响。方法 利用NO发生剂(NOC)5和NOC18于体外预处理约氏疟原虫裂殖体，然后接种小鼠，尾静脉采血，吉姆萨薄血膜染色，计数小鼠感染率。结果 伴随NOC处理浓度的升高或处理时间的延长，小鼠出现感染的时间明显滞后，感染率显著下降。结论 NO具有明显削弱约氏疟原虫裂殖子感染力的作用，这种效应表现为剂量依赖性和时间依赖性。 |
| 关 键 词： | 一氧化氮 约氏疟原虫 裂殖子 |
| 文章编号： | 1001-0580(2004)08-0975-02 |
| 修稿时间： | 2004-05-20 |
Research on effect of nitric oxide on infectivity of merozoite of plasmodium yoelii |
|
| YAN Jian-zhong,LIU Jun,DENG Li-jun,et al.. Research on effect of nitric oxide on infectivity of merozoite of plasmodium yoelii[J]. Chinese Journal of Public Health, 2004, 20(8): 975-976 | |
| Authors: | YAN Jian-zhong LIU Jun DENG Li-jun et al. |
| Affiliation: | YAN Jian-zhong,LIU Jun,DENG Li-jun,et al.College of Basic Medical Sciences,China Medical University |
| Abstract: | Objective To clarify effect of nitric oxide on infectivity of merozoite.Methods P.yoelii schizonts collected and treated with NO donors (NOC5 and NOC18) in vitro,were injected into abdominal cavity of mice.Infective rate was assessed by the microscopic examination of Giemsa-stained smears of tail blood.Results As concentration of NO donor was hoisted and treated time was prolonged,the infective rate of mice decreased obviously and infection occurred late.Conclusion Exogenous nitric oxide was able to weaken infectivity of P.yoelii merozoite in a time and dose dependent manner. |
| Keywords: | nitric oxide plasmodium yoelii merozoite |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |