The MHC2TA 1614 C>G gene polymorphism is associated with risk of developing acute coronary syndrome |
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| Affiliation: | 1. Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;2. Department of Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;3. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;4. Department of Sociomedicine, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico;5. Immunogenomics and Metabolic Diseases Laboratory, Instituto Nacional de Medicina Genómica, Mexico City, Mexico;1. Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran;2. Pediatrics Center of Excellence, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;3. Research Center for Immunodeficiencies, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran;5. Molecular Immunology Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA;2. Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA;1. Pediatrics Center of Excellence, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;2. Research Center for Immunodeficiencies, Children''s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;3. Molecular Immunology Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;5. Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran;6. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran;1. IRCCS ‘Casa Sollievo della Sofferenza’, Division of Gastroenterology, San Giovanni Rotondo, Italy;2. IRCCS ‘Casa Sollievo della Sofferenza’, Unit of General Surgery 2nd and Thoracic Surgery, San Giovanni Rotondo, Italy;3. IRCCS ‘Casa Sollievo della Sofferenza’, Bioinformatics Unit, San Giovanni Rotondo, Italy;4. Gastroenterology Unit 2, AOU Careggi Hospital, Florence, Italy |
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| Abstract: | BackgroundInflammation plays an essential role in the development and progression of atherosclerotic lesions. The major histocompatibility complex class II trans-activator (MHC2TA) is considered an important molecule in the inflammatory process regulation. The aim of the present study was to evaluate the role of MHC2TA gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS).MethodsThree polymorphisms (−168 A>G, 1614 C>G, and 2536 G>A) of the MHC2TA gene were analyzed by 5′ exonuclease TaqMan genotyping assays in a group of 297 patients with ACS and 283 healthy controls. Haplotypes were constructed after linkage disequilibrium analysis.ResultsThe 1614 C allele and CC genotype were associated with risk of developing ACS (PC = 0.014, OR = 1.37 and PC = 0.006, OR = 1.90, respectively). Based on Hosmer–Lemeshow Goodness of Fit test, the recessive model was selected to estimate risk between ACS patients and controls adjusted by cardiovascular risk factors using a multiple logistic analysis. In this case, the OR adjusted was 1.78 for the 1614 CC genotype (P = 0.023). The analysis of linkage disequilibrium showed one risk haplotype (ACG) and one protective haplotype (AGG) for developing ACS (P = 0.02, OR = 1.5 and P = 0.04, OR = 0.72, respectively).ConclusionThe results suggest that MHC2TA 1614 gene polymorphism could be involved in the risk of developing ACS. |
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