A new hepatitis B virus vaccine escape mutation in a renal transplant recipient. |
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Authors: | A Arzu Sayiner Harun Agca Aylin Sengonul Ali Celik Mesut Akarsu |
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Institution: | Department of Clinical Microbiology, Dokuz Eylul University School of Medicine, 35340 Inciralti, Izmir, Turkey. arzu.sayiner@deu.edu.tr |
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Abstract: | Surface antigen mutations of hepatitis B virus (HBV) may lead to immune escape and cause failure of immunization. In this report, the development of a chronic HBV infection in a vaccinated renal transplant recipient with pre-existing anti-HBs antibody is documented. The sequencing data showed that the HBV strain carried five amino acid substitutions in the major hydrophilic region of the S protein, one (sS143L) located at the "a" determinant. A commercial HBsAg assay failed to detect the mutant antigen. |
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