首页 | 本学科首页   官方微博 | 高级检索  
     


Systemic oxidative stress could predict assisted reproductive technique outcome
Authors:A. Ahelik  R. Mändar  P. Korrovits  P. Karits  E. Talving  K. Rosenstein  M. Jaagura  A. Salumets  T. Kullisaar
Affiliation:1. Department of Microbiology, Faculty of Medicine, University of Tartu, Ravila 19, Tartu, 50411, Estonia
2. Competence Centre on Health Technologies, Tartu, 50410, Estonia
3. Andrology Center, Tartu University Hospital, Tartu, 50406, Estonia
4. Nova Vita Clinic, Tallinn, 11316, Estonia
5. Department of Biochemistry, Faculty of Medicine, University of Tartu, Tartu, 50411, Estonia
Abstract:

Purpose

Previous studies have indicated that OxS (oxidative stress) may appear as a possible reason for poor ART outcome. Our aim was to study OxS levels in both partners of couples seeking Assisted reproduction Technology (ART).

Methods

Altogether 79 couples were recruited. Oxidative DNA damage (8-OHdG) and lipid peroxidation (8-EPI) were measured, and clinical background and ART outcomes were recorded.

Results

Both OxS markers accurately reflected clincal conditions with prominent negative effects attributable to genital tract infections, endometriosis, uterine myoma and smoking. Furthermore, the level of OxS was also affected by partner’s state of health. The highest 8-EPI levels were detected in both partners when biochemically detectable pregnancies did not develop into clinically detectable pregnancies (in women, 97,8 ± 16,7 vs 72.9 ± 22,9, p = 0.007; in men, 89.6 ± 20,4 vs 72,1 ± 22,6, p = 0.049).

Conclusions

To conclude, high grade systemix OxS in both partners may negatively affect the maintenance and outcome of pregnancy. Applying the detection of OxS in ART patients may select patients with higher success rate and/or those who require antioxidant therapy. This would lead to improvement of ART outcome as well as natural fertility.

Electronic supplementary material

The online version of this article (doi:10.1007/s10815-015-0466-6) contains supplementary material, which is available to authorized users.
Keywords:8-EPI (8-iso Prostaglandin F)   8-OHdG (8-hydroxy-2’-deoxyguanosine)   ART (assisted reproductive technique)   Infertility   OxS (oxidative stress)   ROS (reactive oxygen species)
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号