Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women |
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Authors: | Changlong Guo Xiaofang Cao Qidi Wang Guangyu Wang Lisha An Meng Du Yue Qiu Ying Yang Hui Li Yuting Wang Shuo Wang Xingyu Wang Xu Ma |
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Affiliation: | 1. National Research Institute for Family Planning, 12 Dahuisi Road, Haidian, Beijing, 100081, China 2. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China 3. Graduate School of Peking Union Medical College, Beijing, China 4. World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
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Abstract: | PurposeThe aim of this study was to investigate whether polymorphisms in the tissue inhibitor of metalloproteinase 3 gene (TIMP3) are associated with the risk of preeclampsia (PE) in Han Chinese women.MethodsNine single TIMP3 tag-single nucleotide polymorphisms were selected by Haploview and genotyped using the Sequenom method in 181 preeclamptic and 203 healthy pregnant women from eastern China.ResultsThe allele frequencies of the tag-single nucleotide polymorphisms were not significantly different between groups (P > 0.05). However, the genotype distribution of rs135025 was shown to differ between the multigravidity PE subgroup (>3) and controls under additive (P = 0.018) and recessive models (P = 0.008), while the genotype distribution of rs80272 differed significantly between the severe PE subgroup and controls under additive (P = 0.014) and dominant models (P = 0.041). Moreover, the H2 haplotype (A-C-G-T-A-A-G-C-G) was found to be associated with the risk of PE (P = 0.035).ConclusionsGenotypes of rs135025 and rs80272 in TIMP3 may therefore influence susceptibility to PE, and pregnant women carrying the H2 haplotype might be more prone to developing PE.Electronic supplementary materialThe online version of this article (doi:10.1007/s10815-015-0529-8) contains supplementary material, which is available to authorized users. |
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Keywords: | Tissue inhibitors of matrix metalloproteinases 3 Preeclampsia Genetic polymorphism Haplotype analysis |
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