阿司匹林缓释胶囊的释放度与生物利用度研究

目的 :制备阿司匹林缓释胶囊 (A -SRC) ,并对其释放度与生物利用度进行研究。方法 :通过测定A -SRC的释放度 ,进行释放机制的研究 ;测定家兔体内血药浓度 ,研究A -SRC的相对生物利用度。结果 :A -SRC体外释放符合零级动力学过程。该制剂相对于其普通片剂释药稳定、生物利用度高。结论 :A -SRC缓释效果明显 ,给药后血药浓度较为平缓 ,持续作用时间长 ,可减少给药次数 ;由于A -SRC采用轻质辅料具漂浮性能 ,缓慢释药 ,因而有利于降低其对胃肠道的刺激性及其他不良反应。

Study on the Release Rate and Bioavailability of Aspirin Sustained Release Capsules

OBJECTIVE:Aspirin sustained release capsules(A-SRC) were prepared The release rate and bioavailability of A-SRC were studies METHODS:To study release mechanism by determining dissolution rate and to study relative bioavailability of A-SRC by determining serum concentrations in rabbits RESULTS:The release profile of A-SRC fitted zero-order kinetics This sustained release preparation had good release stability and high bioavailability in comparison with commonly-used aspirin sustained release capsules CONCLUSION:A-SRC showed obviously sustained release effect The drug concentration in blood kept steady and lasted long after oral administration,therefore the times of administration could be decreased Because the light-excipients were used in A-SRC,which had floating properties and could make drug release slowly A-SRC could decrease the irritations to gastrointestinal tract and other side effects