血清涎酸测定在食管癌诊断及动态监测中的意义

研究血清涎酸对食管癌诊断及监测的临床价值。方法：采用ＨｏｎｄａＳ改良的荧光测定法，对１０７例食管癌，８３例良性疾病患者和１０３例健康你进行血清ＳＡ测定。结果：食管癌组患者血清ＳＡ含量显著高于良性疾病组和健康人组；不同组织类型和临床分期的食管癌患者血清ＳＡ水平间也有明显差异，血清ＳＡ水平与肿瘤的去分化程度和临床分期成正比关系；

The Clinical Singnificance of Serum Sialic Acid Measurement in the Diagosis and Dynamic Inspection of Esophageal Cancer

Objective: To study the clinical significance of serum sialic acid (SA) measurement in the diagnosis and dynamic inspection of esophageal cancer. Methods:The serum SA concentration of 117 esophageal cancer patients, 83 benign disease patiens and 103 normal persons were measured by Honda S. modified fluoresence method. Results: The serum SA level in esophagal cancer patient group was markedly higher than that in the other tow groups. The serum SA levels among the esophageal cancer patients in different tissue types and different clinical pathological stages were also obviously difference (P<0.01) .The serum SA levels was positively related with the differentiation removing degree and clinical pathological advance of the cancer. Moreover, the serum SA levels of the patients who accepted operation to remove the cancer 4 weeks before were markedly lower than that before operation, which would be rebounded again to a high level if the cancer had a relapse or transference late. Conclusions:There was marked clinical significance to measure serum SA for esophageal cancer diagnosis, treatment evaluation and monitoring after operation.