Atrial natriuretic polypeptides: structure-activity relationship in the central action--a comparison of their antidipsogenic actions |
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| Authors: | H Itoh K Nakao G Katsuura N Morii S Shiono T Yamada A Sugawara Y Saito K Watanabe K Igano |
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| Institution: | 1. Second Division, Department of Medicine, Kyoto University School of Medicine, Kyoto Japan;2. Radioisotope Research Center, Kyoto University, Kyoto Japan;3. Shionogi & Co., Osaka Japan;1. Green Chemistry and Process Enhancement Technology, National & Local Joint Engineering Research Center for Mineral Salt Deep Utilization, Huaiyin Institute of Technology, Huai''an, 223003, China;2. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin, 541004, China;1. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA;1. Department of Anatomy, Embryology and Physiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;2. Biogazelle, Ghent, Belgium;3. Center of Molecular Biology (ZMBH), University of Heidelberg, Heidelberg 69120, Germany;1. Department of Chemistry, City University of Hong Kong, Hong Kong SAR, PR China;2. School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, PR China;3. City University of Hong Kong Shenzhen Research Institute, Shenzhen 518057, PR China;1. Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, 2970 Hørsholm, Denmark;2. Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, 2970 Hørsholm, Denmark;3. Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark;1. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK;2. Department of Chemistry, RCSI, 123 St. Stephens Green, Dublin 2, Ireland;3. SSPC, Synthesis and Solid State Pharmaceutical Centre, Ireland |
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| Abstract: | The structure-activity relationship of atrial natriuretic polypeptides (ANPs) in the central action was investigated by examining the suppressive effects of the intracerebroventricular (i.c.v.) administration of ANPs on water intake induced by the i.c.v. injection of angiotensin II (AII) (0.1 nmol) in rats. alpha-Rat ANP (alpha-rANP), alpha-human ANP, alpha-rANP4-28 and alpha-rANP5-28 at a dose of 1.5 nmol exerted equipotent antidipsogenic actions, while alpha-rANP7-23-amide had no inhibitory effect on water drinking at this dose. |
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