Immune reconstitution after purified autologous and allogeneic blood stem cell transplantation compared with unmanipulated bone marrow transplantation in children |
| |
Authors: | Schwinger Wolfgang Weber-Mzell Daniela Zois Birgit Rojacher Tanja Benesch Martin Lackner Herwig Dornbusch Hans Juergen Sovinz Petra Moser Andrea Lanzer Gerhard Schauenstein Konrad Ofner Petra Handgretinger Rupert Urban Christian |
| |
Affiliation: | Division of Paediatric Haematology/Oncology, Department of Paediatrics; Medical University of Graz, Graz, Austria. wolfgang.schwinger@medunigraz.at |
| |
Abstract: | Immune reconstitution is critical for the long-term success of haematopoietic stem cell transplantation (HSCT). We prospectively analysed immune reconstitution parameters after transplantation of autologous (group 1; n = 10) and allogeneic (group 2; n = 12) highly purified CD34+ peripheral blood stem cells (PBSC) and unmanipulated allogeneic bone marrow (BM) (group 3; n = 9) in children. Median follow-up after HSCT was 56 (group 1), 61 (group 2), and 40.5 months (group 3). Median CD34-cell dose transplanted in the three groups was 9.4 x 10(6)/kg, 20.3 x 10(6)/kg, and 4.25 x 10(6)/kg recipient's body weight (BW) respectively. Complete haematopoietic engraftment was seen in all patients without any significant differences between the three groups. T-cell reconstitution at 6 months was significantly delayed in autologous peripheral blood stem cell transplantation (PBSCT) compared with allogeneic BM transplantation (P < 0.028) and allogeneic PBSCT (P < 0.034). At 3 months after transplantation numbers of CD56+/3- natural killer cells were higher in the allogeneic PBSC group (P < 0.01) compared with the BM group. The numbers of proven bacterial and viral infections were equally distributed between the three groups. In conclusion, recipients of allogeneic highly purified CD34+ PBSC or unmanipulated BM have higher lymphocyte subset counts at 6 months after transplantation than recipients of autologous CD34-selected PBSC. Infection rates and outcome, however, were not significantly different. |
| |
Keywords: | immune reconstitution transplantation purified blood stem cells bone marrow children |
本文献已被 PubMed 等数据库收录! |
|