Podophyllotoxin analogues: synthesis and computer modelling investigation of structure-activity relationships |
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| Authors: | A R Beard M G Drew P Hilgard B D Hudson J Mann S Neidle L F Wong |
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| Affiliation: | Department of Chemistry, University of Reading, Whiteknights, UK. |
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| Abstract: | The conformations of four 2-substituted-4-deoxy-analogues of podophyllotoxin have been studied using data obtained from X-ray structure determinations and molecular modelling studies. In these, root mean square differences between these structures and those of the cytotoxic agents 6'-bromopodophyllotoxin and colchicine were determined. Attempts have been made to correlate structure with the available biological activity data. |
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