| Abstract: | New antigens in SV40 transformed cells. I. Demonstration of three new antigenic constituents in several cell lines of different species transformed by the SV40 The soluble components of different cell lines in various species (hamster, mouse, rat and dog) were compared by means of precipitation test in agar. Some lines were spontaneously transformed, others were transformed by SV40 virus and oncogenic viruses. The utilization of rabbit and hamster antisera, specific for a clone of SV40 transformed cells (TSV5Cl2) demonstrated the presence of three new antigens in the various cell strains transformed by SV40. These antigens are different from the nuclear T antigen and probably also from the transplantation antigen located on the cell membrane. |
