垂体柄中断综合征病例临床特点分析简

目的 探讨垂体柄中断综合征的临床特点,提高对该病的诊疗水平.方法 回顾性分析该院7例垂体柄中断综合征患者的临床表现、内分泌功能试验和影像学检查特点.结果 7例患者中有6例生长激素绝对缺乏,1例生长激素相对缺乏;4例存在低促性腺激素性性腺功能减退;4例存在中枢性甲低;6例出现肾上腺皮质功能低下.磁共振检査显示患者垂体前叶体积小,垂体柄缺如,垂体后叶异位.结论 垂体柄中断综合征发病率低,诊断主要依据为垂体磁共振检查,临床表现以生长激素缺乏为主,多合并促性腺激素释放激素、促肾上腺皮质激素和促甲状腺激素不同程度缺乏.

Clinical analysis of pituitary stalk interruption syndrome

Objective To investigate the clinical characteristics of pituitary stalk interruption syndrome,and to improve the diagnosis and treatment of the disease. Methods Seven cases were retrospectively reviewed in terms of clinical manifestations, endocrine function test and imaging features. Results 6 cases of 7 patients had absolute deficiency of growth hormone, 1 ease had relative deficiency of growth hormone;4 eases had deficiency of gonadotropin-refeasing hormone;4 eases had deficiency of secondary hypothyroidism;6 cases had adrenoeortieal insufficiency. MRI inspection shows reduced volume of the anterior pituitmT,vague pituitm7 stalk,eetopie posterior pituitm7. Conclusion The incidence of PSIS is low. Diagnosis is made primarily based on MRI. PSIS is characterized by GH deficiency,and mostly combined with GnRH ,ACTH and TSH deficiency of different extent.