肺癌及其癌旁组织、良性病变 survivin 的表达意义

目的探讨survivin在肺癌及其癌旁组织、良性病变的表达与肺癌发生、发展、预后的关系。方法以免疫组织化学法检测肺癌标本60例、癌旁组织15例、良性病变10例中survivin蛋白表达情况,用SPSS软件分析数据。结果 （1）survivin在肺癌高表达、在癌旁组织低表达、良性病变无表达。（2）survivin阳性染色主要位于细胞质,部分位于胞核,部分胞质胞核均表达。（3）survivin胞质表达与肺癌患者年龄、肿瘤大小、组织类型、分化程度、病理分期无关（P〉0.05）,与淋巴结转移有关,（P〈0.05）。（4）Kaplan-Meier生存分析显示：survivin胞质阳性生存率高于阴性表达者,有统计学差异（P〈0.05）。（5）Cox多因素分析显示：淋巴结转移和survivin胞质表达是肺癌预后的高危因素,危险度为：18.882、3.546。结论 （1）survivin表达与肺癌的发生有关。（2）survivin胞质表达与肺癌淋巴结转移有关而与其他病理特征无关。（3）survivin胞质表达和淋巴结转移是肺癌患者独立预后因素。

Significance of the expressions of survivin in lung cancer and para-carcinoma tissues and benign lesion

Objective To analyze the survivin expressions in lung cancer and para-carcinoma tissues and benign lesion,and to investigate the effects of survivin on the occurrence,development,prognosis of lung cancer. Methods The expression of survivin protein were examined by immunohistochemical staining in samples from lung cancer and para-carcinoma tissues and benign lesion. The data was analyzed by SPSS13. 0 software. Results The expression rate of survivin was high in lung cancer and low in para-carcinoma tissues, nought in benign lesion. Survivin positive staining was located mainly in cytoplasm and partly in nuclear or nuclear and cytoplasm. The cytoplasmic expression of survivin in lung cancer was irrelevant with age,tumor size,pathological stages,differentiation,histological types（ P ＆gt; 0. 05）,however,it was related with lymph node metastasis（ P ＆lt; 0. 05）. Kaplan-Meier survival analysis showed that survival rate of positive expression of survivin in cytoplasm was higher than negative in lung cancer patients,and the difference was significant（ P ＆lt; 0. 05）. Multivariate Cox regression analysis showed that the cytoplasmic expression of survivin and lymph node metastasis were significant prognostic factors for lung cancer,and the risk ratios were 18. 882 and 3. 546,respectively. Conclusions The expression of survivin is related with occurrence of lung cancer. The cytoplasmic expression of survivin is irrelevant with clinicopathological characteristics of lung cancer,but it is related with lymph node metastasis. The expressions of survivin in cytoplasm and lymph node metastasis are independent prognostic factors.