联合检测 CEA、CA19-9、CA125 对恶性胸腔积液的诊断价值简

目的 评价联合检测胸水中CEA、CA125、CA19-9对良恶性胸腔积液的鉴别诊断价值.方法 应用化学发光分析法同时检测30例恶性胸腔积液和46例良性胸腔积液的CEA、CA125、CA19-9水平.结果 恶性胸腔积液组的CEA、CA125、CA19-9的含量分别为（137.52±105.20）μg·L-1、（308.5±268.7）U·mL-1、（85.33±70.50）U·mL-1显著高于良性胸腔积液组的（3.08±2.01）μg·L-1、（21.31±11.08）U·mL-1、（11.38±9.20）U·mL-1.联合检测CEA、CA125、CA19-9诊断恶性胸腔积液的敏感度达93.3%,显著高于单项或两项检测的敏感性,其特异性也达89.2%.结论 胸腔积液CA125、CA19-9和CEA的联合检测对鉴别良恶性胸腔积液有重要参考价值.

Diagnostic value of CA125,CA19-9 and CEA in pleural effusions from malignant perfusions

Objective To study the diagnostic value of CA125,CA19-9 and CEA of pleural effusions in benign and malignant pleural effusions. Methods CEA,CA125and CA19-9 in pleural effusions from benign and malignant cases were detected by chemiluminesceney. Results The best clinical criteria of CEA,CA125 and C199 in malignant peffusions were （ 137.52 ± 105.20）μg·L^-1 （308.5 ± 268.7） U·mL-1 （ 85.33 ± 70.50）U·mL-1 significantly higher than those in benign pleural effusions which were （3.08 ± 2.01）μg·L^-1. （21.31 ± 11.08）U·mL-1. （11.38 ± 9.20）U·mL-1. Combined detection of CEA, CA125, CA19-9 sensitivity was 93.3% , specificity was 89.2%. Conclusions Combined detection of CA125, CA19-9 and CEA can improve the differentiation of malignant pleural effusions from benign.