高能中波紫外线联合他克莫司软膏治疗白癜风疗效观察

【摘要】 目的 观察高能中波紫外线联合0.1﹪他克莫司软膏治疗白癜风疗效及安全性。方法 90例患者随机分为3组，每组30例。A组（治疗组）：高能中波紫外线联合0.1﹪他克莫司软膏治疗。B组（对照组1）：仅高能中波紫外线治疗，治疗方法同于A组。C组（对照组2）：仅每天2次外用0.1﹪他克莫司软膏于患处。各组观察时间≤12周，治疗过程中拍照片对比。结果 在≤12周的疗程结束后，A组（治疗组）总有效率为83.33﹪，B组（对照组1）及C组（对照组2）总有效率分别为50.0﹪和43.33﹪，A组和B、C两组分别比较总有效率差异具有显著性意义（P＜0.01）。A组分别和B、C两组比较平均复色时间差异具有显著性意义（P＜0.05）。3组患者不同部位皮损疗效比较差异具有显著性意义（P＜0.05）。3组患者治疗过程中不良反应轻微，对症处理后不影响继续治疗。结论 高能中波紫外线联合0.1﹪他克莫司软膏治疗白癜风疗效好安全性高。

High-energy ultraviolet B plus tacrolimus ointment in the treatment of vitiligo: a clinical observation

【Abstract】 Objective To observe the therapeutic efficacy and safety of high-energy UVB in combination with the 0.1% tacrolimus ointment in the treatment for vitiligo. Methods 90 patients were randomly divided into 3 groups. Each group included 30 patients. Group A as treatment group was treated with high-energy UVB therapy as well as the 0.1% tacrolimus ointment. Group B as comparison group 1 was treated only with high-energy UVB therapy. The method of the therapy was the same as Group A. Group C as comparison group 2 was treated only with the 0.1% tacrolimus ointment by means of applying it to affected parts, twice a day. The observing period for each group was no more than 12 weeks. Photos were taken and compared during the treatment. Results After completing no more than 12 week’s treatment, the total rate of efficacy was 83.33% for Group A (the treatment group). The total rate of efficacy was 50.0% and 43.33% respectively for Group B (the comparison group 1) and Group C (the comparison group 2). The differences of the total rates of efficacy were of significance by comparison respectively between Group A and Group B and between Group A and Group C (p<0.05). The differences of the average time of color restoration were of significance by comparison respectively between Group A and Group B and between Group A and Group C (p<0.05). The therapeutic efficacy of lesions to different parts was of significance by comparison for 3 groups of patients (p<0.05). The adverse reaction of 3 groups’ patients was trivial during the treatment, and it did not affect following-up therapy after symptomatic treatment. Conclusions: The therapeutic efficacy is great and the safety is high in the treatment for vitiligo by combining high-energy UVB with the 0.1% tacrolimus ointment.