翼状胬肉切除联合结膜自体移植术中纤维蛋白胶应用的Meta分析

目的 探讨纤维蛋白胶(FG)在翼状胬肉切除联合结膜自体移植术中的临床疗效.方法 应用循证医学的研究方法检索美国国立医学图书馆、荷兰医学文摘、循证医学数据库、中国知网、万方数据库、中国期刊全文数据库及维普中文科技期刊数据库并辅以手工检索,遵循Cochrane Handbook 5.0质量评价原则评价纳入研究的质量,采用RevMan5.0软件进行统计学处理.结果 纳入7项随机对照实验,共366只眼.Meta分析结果显示:与缝线组相比,FG组在术后复发方面,差异有统计学意义RR=0.28,95%CI(0.10,0.76),P=0.01];在术后并发症方面,两组比较差异无统计学意义RR=2.53,95%CI(0.47,13.51),P=0.28].结论在翼状胬肉切除联合结膜自体移植术中,应用FG封闭伤口可降低术后复发.(中华眼科杂志,2011,47:550-554)

Abstract：

Objective To evaluate the clinical efficacy of FG for attaching conjunctival autografts in pterygium surgery. Methods Search was conducted in Pubmed, Embase, Cochrane Library, CNKI, Wanfang database, CBM and VIP,and hand-search was also performed, the methodological quality were carried out according to evidence-based medicine (EBM). The qualities of the randomized controlled trials(RCT) were evaluated according to the Cochrane Handbook for Systematic Reviews of Interventions Version 5.0. The Cochrane Collaboration's software RevMan 5.0 was used for Meta-analysis. Results Only 7 trials, involving 366 eyes, were included. Meta-analysis showed that significant differences were found between the FG and suture in recurrence RR=0.34, 95%CI(0.15,0.80), P=0.01], but there is no difference in reducing the complications RR=2.53,95%CI(0.47,13.51),P=0.28]. ConclusionFibrin glue-assisted conjunctival autograft in pterygium surgery reduces postoperative recurrence.

Meta-analysis of fibrin glue for attaching conjunctival autografts in pterygium surgery

Objective To evaluate the clinical efficacy of FG for attaching conjunctival autografts in pterygium surgery. Methods Search was conducted in Pubmed, Embase, Cochrane Library, CNKI, Wanfang database, CBM and VIP,and hand-search was also performed, the methodological quality were carried out according to evidence-based medicine (EBM). The qualities of the randomized controlled trials(RCT) were evaluated according to the Cochrane Handbook for Systematic Reviews of Interventions Version 5.0. The Cochrane Collaboration's software RevMan 5.0 was used for Meta-analysis. Results Only 7 trials, involving 366 eyes, were included. Meta-analysis showed that significant differences were found between the FG and suture in recurrence RR=0.34, 95%CI(0.15,0.80), P=0.01], but there is no difference in reducing the complications RR=2.53,95%CI(0.47,13.51),P=0.28]. ConclusionFibrin glue-assisted conjunctival autograft in pterygium surgery reduces postoperative recurrence.