非小细胞肺癌1638例治疗及预后探讨

目的 结合2009 TNM分期和患者临床资料分析探讨非小细胞肺痛的预后及其影响因素.方法 回顾性分析2001年1月至2005年1月接受手术的1638例非小细胞肺癌患者的临床资料,并对其预后及影响其预后的临床病理因素进行分析.其中男性1083例,女性555例,平均年龄59.5岁.结果 非小细胞肺癌患者术后总体1年、3年及5年生存率分别为80.0%、52.3%及39.0%.单因素分析显示影响预后的因素为支气管断端是否阳性、手术方式、T分期、N分期、淋巴结清扫个数(0～、10～及＞20个)、淋巴结清扫组数和术后放疗(P＜0.05).Cox回归多因素分析提示,手术方式(P=0.001)、T分期(P=0.000)、N分期(P=0.000)和淋巴结清扫个数(P=0.013)是独立的预后影响因素.结论 非小细胞肺癌总体预后差.手术方式、T分期、N分期及淋巴结清扫个数均是其预后的独立影响因素.

Abstract：

Objective To study the prognosis and prognostic factors of non-small-cell lung carcinoma(NSCLC)according the new TNM stage system.Methods Clinic data of 1638 inpatient cases admitted from January 2001 to January 2005 were retrospectively reviewed.There were 1083 male and 555 female patients in the study and the average age was 59.5 years.All the patients received surgical procedures.Results The overall 1,3,5-year survival rate was 80.0%,52.3%,39.0%.The main prognostic factors were bronchial stump,operation type,T stage,N stage,the number of lymph nodes (LNs)in lymph nodes dissection(1-10,11-20,and＞20),overall N stations(＜4 and ≥4)and postoperative radiotherapy(all P＜0.05).Cox regression suggested that T stage(P = 0.000),N stage (P=0.000),operation type(P=0.001)and LNs(P = 0.013)were independent factors affecting the prognosis.Conclusions The overall survival rate of NSCLC is poor.T stage,N stage,operation type and LNs are independent factors affecting the prognosis.

Treatment and prognostic analysis of 1638 patients with non-small cell lung cancer

Objective To study the prognosis and prognostic factors of non-small-cell lung carcinoma(NSCLC)according the new TNM stage system.Methods Clinic data of 1638 inpatient cases admitted from January 2001 to January 2005 were retrospectively reviewed.There were 1083 male and 555 female patients in the study and the average age was 59.5 years.All the patients received surgical procedures.Results The overall 1,3,5-year survival rate was 80.0%,52.3%,39.0%.The main prognostic factors were bronchial stump,operation type,T stage,N stage,the number of lymph nodes (LNs)in lymph nodes dissection(1-10,11-20,and＞20),overall N stations(＜4 and ≥4)and postoperative radiotherapy(all P＜0.05).Cox regression suggested that T stage(P = 0.000),N stage (P=0.000),operation type(P=0.001)and LNs(P = 0.013)were independent factors affecting the prognosis.Conclusions The overall survival rate of NSCLC is poor.T stage,N stage,operation type and LNs are independent factors affecting the prognosis.