影响慢性咳嗽患者生活质量的相关因素分析

目的 探讨影响慢性咳嗽患者生活质量的相关因素.方法 按照慢性咳嗽病因诊断流程入选患者.通过支气管乙酰甲胆碱激发试验测定患者气道反应性,记录患者莱斯特咳嗽问卷(LCQ)评分、咳嗽严重程度[采用视觉模拟尺(VAS)评价]、咳嗽症状积分,并分析其相关性.结果 100例慢性咳嗽患者纳入本研究.引起慢性咳嗽的前5位病因依次为咳嗽变异性哮喘、感染后咳嗽、变应性咳嗽、嗜酸粒细胞性支气管炎、上气道咳嗽综合征.不同病因、不同性别问的LCQ评分筹异无统计学意义(P>0.05).女性患者LCQ中的生理领域评分和心理领域评分显著低于男性;支气管乙酰甲胆碱激发试验阳性患者LCQ评分较阴性患者显著减低(t=-2.22,P<0.05).经过2周针对性治疗后,70例患者LCQ评分较治疗前显著提高(P值均<0.01).100例慢性咳嗽患者LCQ评分与年龄、咳嗽严重程度、咳嗽症状积分呈负相关(r分别为-0.239、-0.470、-0.448,P值均小于0.05),与BMI无相关性(r=-0.029,P>0.05).结论 性别与年龄可能影响慢性咳嗽患者的生活质量,LCQ、咳嗽严重程度、咳嗽症状积分可协同评估咳嗽的严重程度及疗效.

Abstract：

Objective To constitute a correlation with the subjective indicators by investigation of the causes and clinical features in patients with chronic cough.Methods Totally 100 patients with chronic cough were recruited followed a diagnostic program.Airway responsiveness[by methacholine challenge test (MCT)],Leicester cough questionnaire(LCQ),visual analogue scale(VAS),cough score,age,gender and disease duration were all recorded for analysis.Results The top five causes of chronic cough in these patients were variant asthma,post infectious cough,atopic cough,eosinophilic bronchitis and upper airway cough syndrome.LCQ total score was negatively correlated with age and the VAS score(r=-0.239 and -0.470 respectively,all P<0.05),while no difference was found among patients with different causes of disease or gender(F=1.233,t=1.918,all P>0.05)and no correlation was found with BMI(r=-0.029,P>0.05).The physiological and psychological field score in female patients significantly reduced(t=2.174,1.990,P<0.05),and LCQ total score of MCT positive patients obviously reduced than negative ones(t=-2.22,P<0.05).After the treatment of two weeks,LCQ three component field and total score could be improved significantly(all P<0.01).Conclusion Gender and age may have some impact on the quality of life in patients with chronic cough.LCQ,VAS and cough score should be used to assess cough severity and evaluate therapeutic effect in patients with chronic cough.

An analysis of factors for quality-of-life in patients with chronic cough

Objective To constitute a correlation with the subjective indicators by investigation of the causes and clinical features in patients with chronic cough.Methods Totally 100 patients with chronic cough were recruited followed a diagnostic program.Airway responsiveness[by methacholine challenge test (MCT)],Leicester cough questionnaire(LCQ),visual analogue scale(VAS),cough score,age,gender and disease duration were all recorded for analysis.Results The top five causes of chronic cough in these patients were variant asthma,post infectious cough,atopic cough,eosinophilic bronchitis and upper airway cough syndrome.LCQ total score was negatively correlated with age and the VAS score(r=-0.239 and -0.470 respectively,all P<0.05),while no difference was found among patients with different causes of disease or gender(F=1.233,t=1.918,all P>0.05)and no correlation was found with BMI(r=-0.029,P>0.05).The physiological and psychological field score in female patients significantly reduced(t=2.174,1.990,P<0.05),and LCQ total score of MCT positive patients obviously reduced than negative ones(t=-2.22,P<0.05).After the treatment of two weeks,LCQ three component field and total score could be improved significantly(all P<0.01).Conclusion Gender and age may have some impact on the quality of life in patients with chronic cough.LCQ,VAS and cough score should be used to assess cough severity and evaluate therapeutic effect in patients with chronic cough.