粪菌移植:中西医诊疗思维的碰撞

粪菌移植(FMT)是将健康供者粪便中的功能菌群移植到患者胃肠道内,以期重建患者体内正常菌群的一种疾病治疗方式。西医以FMT方式治疗疾病的历史可追溯至20世纪50年代,经过数十年的探索,其疗效已在多种疾病中得到验证;而中医关于人粪入药的记载更可追溯至公元3世纪,相关理论在历代多部中医著作中均有记载。作为一种已经被写入指南的治疗方式,FMT在治疗难辨梭状芽孢杆菌感染中的作用已在美国、英国等部分国家和地区得到认可,且其临床适应证范围有进一步扩展的趋势。中西方医学两种截然不同的思维模式在应用FMT治疗疾病上产生了奇妙的碰撞。综合中西医医学实践中的菁华,探索更加规范、有效的FMT方式,既是以患者健康为中心的体现,也是中西医学相互促进的体现。

Fecal Microbiota Transplantation:Traditional Chinese Medicine Meets Western Medicine

Fecal microbiota transplantation (FMT) is a therapy of transplanting the functional flora from the feces of a healthy donor into the gastrointestinal tract of a patient to reconstruct the normal flora.The application of FMT in western medicine dates from the 1950s.After decades of development,the efficacy of FMT has been proven in a variety of diseases.The record of FMT in traditional Chinese medicine (TCM) dates early from the 3rd century A.D.,and relevant theories have been recorded in many TCM works in the past dynasties.FMT as a therapy that has been written into guidelines has been accepted by some countries and regions such as the United States and the United Kingdom in the treatment of Clostridium difficile infection,and its clinical indications are expanding.TCM and western medicine,with different medical thoughts,meet in the application of FMT.Exploring a normative and effective FMT procedure reflects not only the patient-centered principle but also the mutual promotion of TCM and western medicine.