| 成纤维细胞生长因子受体信号通路在乳腺癌中的研究进展 |
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| 引用本文： | 郭秋生,曹文明,王晓稼. 成纤维细胞生长因子受体信号通路在乳腺癌中的研究进展[J]. 中国医学科学院学报, 2022, 44(1): 136-141. DOI: 10.3881/j.issn.1000-503X.12873 |
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| 作者姓名： | 郭秋生 曹文明 王晓稼 |
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| 作者单位： | 1.浙江中医药大学,杭州 310053;2.中国科学院大学附属肿瘤医院乳腺内科,杭州 310022 |
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| 基金项目： | 国家自然科学基金(81672597)~~； |
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| 摘 要： | 乳腺癌是女性最常见的恶性肿瘤之一,近年来发病率呈上升趋势,严重威胁女性健康。随着分子生物学技术的进展,发现更多的信号通路与乳腺癌的发生发展相关,其中,成纤维细胞生长因子受体(FGFR)信号通路在乳腺癌细胞增殖、存活、分化、迁移以及凋亡过程中发挥着重要作用。靶向FGFR信号通路的治疗策略在乳腺癌治疗中显示出良好的应用前景。
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| 关 键 词： | 成纤维细胞生长因子受体 乳腺癌 信号传导 靶向治疗 |
| 收稿时间： | 2020-04-07 |
Research Progress of Fibroblast Growth Factor Receptor Signaling Pathway in Breast Cancer |
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| GUO Qiusheng,CAO Wenming,WANG Xiaojia. Research Progress of Fibroblast Growth Factor Receptor Signaling Pathway in Breast Cancer[J]. Acta Academiae Medicinae Sinicae, 2022, 44(1): 136-141. DOI: 10.3881/j.issn.1000-503X.12873 |
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| Authors: | GUO Qiusheng CAO Wenming WANG Xiaojia |
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| Affiliation: | 1.Zhejiang Chinese Medical University,Hangzhou 310053,China;2.Department of Medical Oncology (Breast Cancer),Cancer Hospital of the University of Chinese Academy of Sciences,Hangzhou 310022,China |
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| Abstract: | Breast cancer,one of the common malignant tumors in women,has shown rising incidence in recent years,posing a serious threat to women's health.The advancement of molecular biology facilitates the revealing of the relationships between signaling pathways and breast cancer.Fibroblast growth factor receptor (FGFR) signaling pathway plays an important role in the proliferation,survival,differentiation,migration,and apoptosis of breast cancer cells.Strategies targeting the FGFR signaling pathway thus exhibit a promising prospect in breast cancer treatment. |
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| Keywords: | fibroblast growth factor receptor breast cancer signal transduction targeted therapy |
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