| 外泌体与胰腺癌的发生发展、诊断和治疗 |
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| 引用本文： | 温开凤,武威杰,李学军.外泌体与胰腺癌的发生发展、诊断和治疗[J].基础医学与临床,2019,39(9):1351-1355. |
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| 作者姓名： | 温开凤 武威杰 李学军 |
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| 作者单位： | 北京大学 基础医学院 药理学系,北京,100191;北京大学 基础医学院 药理学系,北京,100191;北京大学 基础医学院 药理学系,北京,100191 |
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| 基金项目： | 国家自然科学基金;国家自然科学基金 |
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| 摘 要： | 在胰腺癌微环境中,不同细胞来源的外泌体通过传递RNA等物质促进了肿瘤的生长、迁移和侵袭,并促进胰腺癌产生对吉西他滨的耐药性。外泌体携带了大量胰腺癌相关信息,可以通过从体液中捕获外泌体并分析其内容物来早期诊断胰腺癌,利用芯片技术可以使检测更加简便快捷。通过阻断外泌体的生成和传递,或者利用外泌体靶向运送抗肿瘤药物是潜在的治疗胰腺癌的方法之一。
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| 关 键 词： | 外泌体 胰腺癌 |
Exosomes in genesis,development, diagnosis and treatment of pancreatic cancer |
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| WEN Kai-feng,WU Wei-jie,LI Xue-jun.Exosomes in genesis,development, diagnosis and treatment of pancreatic cancer[J].Basic Medical Sciences and Clinics,2019,39(9):1351-1355. |
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| Authors: | WEN Kai-feng WU Wei-jie LI Xue-jun |
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| Institution: | (Department of Pharmacology,School of Basic Medical Science,Peking University,Beijing 100191,China) |
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| Abstract: | In the microenvironment of pancreatic cancer,exosomes derived from different cell types promote the growth,migration and invasion of pancreatic cancer by transferring RNA and other substances,while promoting the generation of gemcitabine resistance in pancreatic cancer.Exosomes carry a lot of information about pancreatic cancer.We can early diagnose pancreatic cancer by capturing exosomes from body fluids and analyzing their contents.Using chip technology,detection can be performed easier and faster.One of the potential treatments for pancreatic cancer is blocking the production and transmission of exosomes or transporting antineoplastic drugs with exosomes. |
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| Keywords: | exosomes pancreatic neoplasms |
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