| 转录调节因子FOXN1异常表达引起相关疾病的研究进展 |
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| 引用本文： | 何啸,胡雨萌,宋银宏. 转录调节因子FOXN1异常表达引起相关疾病的研究进展[J]. 基础医学与临床, 2019, 39(2): 264-267 |
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| 作者姓名： | 何啸 胡雨萌 宋银宏 |
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| 作者单位： | 三峡大学 医学院 感染与炎症损伤研究所,湖北 宜昌,443002;三峡大学 医学院 感染与炎症损伤研究所,湖北 宜昌,443002;三峡大学 医学院 感染与炎症损伤研究所,湖北 宜昌,443002 |
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| 摘 要： | 自发现FOXN1缺乏症以来,FOXN1在胸腺发育和皮肤生长中的作用愈来愈受重视。FOXN1是胸腺上皮和T细胞发育的主要调节因子,是维持胸腺发育、功能和稳态的基础。在皮肤中,FOXN1对角质形成细胞和毛囊细胞的分化起关键作用,但潜在的分子机制仍有待进一步阐明。
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| 关 键 词： | FOXN1 TEC SCID 相关疾病 |
Research progress on the diseases caused by abnormal expression of transcription regulator FOXN1 |
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| HE Xiao,HU Yu-meng,SONG Yin-hong. Research progress on the diseases caused by abnormal expression of transcription regulator FOXN1[J]. Basic Medical Sciences and Clinics, 2019, 39(2): 264-267 |
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| Authors: | HE Xiao HU Yu-meng SONG Yin-hong |
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| Affiliation: | (Infection and inflammation Institute,Medical College,China Three Gorges University,Yichang 443002,China) |
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| Abstract: | Since report of FOXN1 deficiency,the function of FOXN1 in thymus and skin has been focused on increasingly.FOXN1 is the critical regulator for the development of thymus epithelial cells which determines the development and maturation of T cells,therefore,FOXN1 is fundamental for thymus growth,function,and homeostasis.In the skin tissue,it also plays a pivotal role in keratinocytes and hair follicle cell differentiation,however,the underlying molecular mechanisms are still not fully elucidated. |
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| Keywords: | FOXN1 TEC SCID related diseases |
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