| 奥氮平与氯氮平治疗精神分裂症对照研究 |
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| 引用本文： | 王康健,张凯,卢伟.奥氮平与氯氮平治疗精神分裂症对照研究[J].山东精神医学,2003,16(3):141-143. |
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| 作者姓名： | 王康健 张凯 卢伟 |
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| 作者单位： | 陕西省西安市精神卫生中心
710061(王康健，张凯)，陕西省西安市精神卫生中心 710061(卢伟) |
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| 摘 要： | 目的 研究奥氮平治疗精神分裂症的疗效及安全性。方法 分析 6 1例用奥氮平治疗 6周的精神分裂症病例 ,并与 6 1例用氯氮平治疗的精神分裂症病例作对照 ,采用阳性及阴性症状量表 (PANSS)的减分率评价疗效 ,用副作用量表 (TESS)评价 6周末的副作用。结果 6周末PANSS量表总分、阳性症状分、阴性症状分和一般病理分与治疗前比较 ,两组差异均有非常显著性 (P <0 .0 1) ,但两组间差异无显著性 (P >0 .0 5 )。于 2周末两组间除一般病理分外 ,余差异均有极显著性 (P <0 .0 1) ;于第四周末一般病理分差异也有非常显著性 (P <0 .0 1) ;副作用两组间比较 ,奥氮平组明显小于氯氮平组。结论 奥氮平治疗精神分裂症疗效好、起效快、副作用小。
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| 关 键 词： | 奥氮平 氯氮平 精神分裂症 |
| 文章编号： | 1009-7201(2003)-03-0141-03 |
| 修稿时间： | 2003年3月20日 |
A study of olanzapine and clozapine in the treatment of schizophrenia |
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| Abstract: | Objective To explore the clinical effect and safety of olanzapine in the treatment of schizophrenia.Methods Sixty one schizophrenic inpatients were treated with olanzapine for six weeks,and were compared with other 61 schizophrenic inpatients treated with clozapine.Clinical efficacy was measured by PANSS,and the adverse reaction by TESS.Results No difference was found in the decreased rate of PANSS at six weekend for two groups,but significant difference was found at two weekend.Side effects in Olanzapine group were slighter than those in clozapine group.Conclusion Olanzapine is effective and safe in the treatment of schizophrenia. |
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| Keywords: | Olanzapine Clozapine Schizophrenia |
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