手足口病患儿机体免疫功能临床研究

目的：探讨手足口病（HFMD）患儿机体免疫功能的变化。方法将236例HFMD患儿分为3组，肠道病毒71型（EV71）感染组（EV71组）99例，柯萨奇病毒A组16型感染110例（CoxA16组），有严重合并症的患儿27例纳入重症组。另将24例疝气患儿纳入对照组。检测并比较患儿外周血各类淋巴细胞亚群百分比的差异。结果HFMD患儿CD3^＋、CD3^＋CD4^＋亚群百分比较对照组下降，且重症患儿更为明显（P＜0．05）。CD3^＋ CD8^＋亚群百分比仅重症组低于对照组（P＜0．05）。重症组CD3^-CD16^＋ CD56^＋亚群百分比较EV71组、CoxA16组和对照组升高（P＜0．05）。HFMD患儿CD3^-CD19^＋、CD19^＋CD23^＋亚群百分比高于对照组，且EV71组升高更明显（P＜0．05）。HFMD患儿CD4^＋CD25^＋ T亚群百分比高于对照组（P＜0．05）。结论 HFMD患儿存在不同程度的免疫功能紊乱；CD3^＋、CD3^＋CD8^＋和CD3^-CD16^＋CD56^＋亚群百分比检测可用于监测HFMD患儿病情。

Clinic study on the immune function in children with hand-foot-mouth disease

Objective To investigate the change of immune function in children with hand-foot-mouth disease （HFMD） .Methods A total of 236 children with HFMD were divided into three groups ,including 99 cases with en-terovirus 71 type infection （EV71 group） ,110 cases with Coxsackie virus A group 16 type infection （CoxA16 group） and 27 cases with severe complications （severe group） .The other 24 children with indirect inguinal hernia were en-rolled as control group .Percentages of lymphocyte subsets in peripheral blood were detected and compared between each group .Results CD3^＋ and CD3^＋ CD4^＋ subsets decreased obviously in HFMD children ,and those in severe group were lower （P〈0 .05） .CD3^＋ CD8^＋ subsets in severe group decreased （P〈0 .05） .CD3-CD16^＋ CD56^＋ sub-sets in severe group increased ,compared with EV71 group ,CoxA16 group and control group （ P〈 0 .05 ） .CD3-CD19^＋ and CD19^＋CD23^＋ subsets in severe group ,EV71 group and CoxA16 group increased ,compared with control group ,and those in EV71 group were higher （P〈0 .05） .CD4＋CD25＋ subsets in severe group ,EV71 group and Cox-A16 group increased ,compared with control group（P〈0 .05） .Conclusion Immune function in children with HFMD might be disordered .Detection of CD3^＋ ,CD3^＋CD8^＋ and CD3-CD16＋CD56＋ subsets could be useful for the monito-ring of pathogenetic condition in children with HFMD .