九通胶囊对小鼠酒精性肝损伤的保护作用

目的研究九通胶囊对小鼠酒精性肝损伤的保护作用。方法对昆明种小鼠经口灌胃给予0.08g/kg.d、0.17g/kg.d、0.5g/kg.d的九通胶囊,30d后,以50%乙醇0.12mL/10g.bw一次灌胃。测定小鼠肝匀浆中甘油三酯(TG)、丙二醛(MDA)、还原性谷胱甘肽(GSH)含量,同时观察肝脏病理变化。结果成功建立了小鼠酒精性肝损伤模型。九通胶囊可抑制乙醇引起的小鼠肝组织中甘油三酯(TG)、丙二醛(MDA)含量的升高(P<0.05),提高肝组织中还原型谷胱甘肽(GSH)含量(P<0.05)。各剂量组肝脏病理改变评分均低于乙醇对照组(P<0.05)。结论九通胶囊对小鼠酒精性肝损伤具有保护作用。

The Protective Effects of Jiutong Capsule on Alcoholic Liver Injury in Mice

Objective To study the protective effects of Jiutong Capsule on ethanol liver injury.Methods KM mice were given Jiutong Capsule orally at the dose of 0.08g/kg.d、0.17g/kg.d、0.5g/kg.d.30 days later,0.12mL/10g.bw(50%) ethanol were intraperitoneally injected.The liver triacylglycerol(TG),malondialdehyde(M DA),and glutathione(GSH) content were measured and liver change of pathomorphism were observed.Results Alcohol-induced liver injury in mice was set up satisfactorily.Liver TG and MDA in test groups were reduced significantly compared with model group(P<0.05).GSH in test group was increased significantly compared with model group(P<0.05).The mice liver tissue fatty degeneration scores in 3 dose groups were decreased as the dose increased,and that in 0.5g/kg.d group was decreased significantly compared with the ethanol control group.Conclusion Jiutong Capsule has protective effects on ethanol liver injury in mice.