替罗非班对经皮冠状动脉介入术患者白细胞介素及C反应蛋白水平的影响

目的 研究替罗非班对经皮冠状动脉介入(PCI)患者白细胞介素(IL)及C反应蛋白(CRP)水平的影响.方法 选取行PCI术治疗的78例急性心肌梗死患者为研究对象,将其完全随机分为常规治疗的对照组(39例)和常规治疗基础上加用替罗非班治疗的观察组(39例),比较2组患者治疗总有效率、PCI术前以及术后24、72 h血清IL-6、IL-8、IL-I0及CRP水平.结果 观察组的治疗总有效率高于对照组97.4％(38/39)比89.7％(35/39)],差异有统计学意义(P＜0.05).观察组和对照组术后24、72 h血清CRP、IL-6、IL-8、IL-10水平均明显低于术前对照组:(10.4±3.1)、(7.6±2.9) mg/L比(13.5±3.7) mg/L,(55±4)、(40 ±4) mg/L比(70±5)mg/L,(67±5)、(48±3)mg/L/比(90±7)mg/L,(8.8±1.3)、(8.0±1.3) mg/L比(9.8±1.5)mg/L；观察组:(7.3±2.8)、(4.7±2.3)mg/L比(13.5±3.7) mg/L,(42±4)、(29±3)mg/L比(69±5) mg/L,(55±5)、(40±3)mg/L比(90±7)mg/L,(7.6±1.3)、(6.8±1.2)mg/L比(9.9±1.5) mg/L],差异均有统计学意义(均P＜0.05)；术后24、72 h,观察组血清IL-6、IL-8、IL-10、CRP水平均明显低于对照组,差异均有统计学意义(均P ＜0.05).结论 替罗非班可明显减低PCI术患者IL及CRP水平,对PCI术患者具有保护作用.

Effects of tirofiban on interleukin and C reactive protein of patients treated with percutaneous coronary in- tervention

Objective To study the effects of tirofiban on interleukin（IL） and C reactive protein （CRP） in patients treated with percutaneous coronary intervention （PCI）.Methods All 78 patients with PCI were randomly divided into the observation group （n =39） and control group （n =39）.The patients in observation group were treated with tirofiban besides conventional therapy; the patients in control group were treated only with conventional therapy.Plasma levels of IL-6,IL-8,IL-10 and CRP were measured and compared before treatment and 24,72 h after treatment.Results The total effective rate in observation group was higher than that in control group97.4% （38/39） vs 89.7% （35/39）,P 〈 0.05].After treatment for 24,72 h,the plasma levels of CRP,IL-6,IL-8 and IL-10 were lower than those before treatment in observation group and control groupcontrol group：（10.4 ± 3.1）,（7.6 ±2.9）mg/L vs （13.5 ±3.7）mg/L,（55 ±4）,（40 ±4）mg/L vs （70 ±5）mg/L,（67 ±5）,（48 ±3）mg/L vs （90 ± 7） mg/L,（8.8 ± 1.3）,（8.0 ± 1.3） mg/L vs （9.8 ± 1.5） mg/L; observation group：（7.3 ± 2.8）,（4.7 ±2.3）mg/L vs（13.5 ±3.7）mg/L,（42 ±4）,（29±3）mg/L vs （69 ±5）mg/L,（55 ±5）,（40 ±3）mg/L vs （90 ± 7） mg/L,（7.6 ± 1.3）,（6.8 ± 1.2） mg/L vs （9.9 ± 1.5） mg/L],and the plasma levels of CRP,IL-6,IL-8 and IL-10 in observation group were lower than those in control group,and the difference was statistically significant （P 〈 0.05）.Conclusion Tirofiban can significandy reduce the levels of interleukin and CRP levels of patients with PCI.