经颅电刺激对大鼠脑梗死后运动功能恢复的影响

目的 :观察经颅皮层电刺激治疗对大鼠脑梗死后运动功能恢复的作用。方法 :选择12 0只SD成年雄性大鼠制作大脑中动脉闭塞 (MCAO)模型 ,将大鼠随机分为治疗组和对照组各 6 0只 ,治疗组在术后 3天给予经颅电刺激治疗 ,对照组术后不进行治疗 ,于术后第 1、2、3、4、5、6周末 ,分别以横木行走试验 (BWT)及运动诱发电位为指标评价大鼠运动功能恢复情况。结果 :经颅磁刺激治疗的大鼠 ,运动功能较对照组明显改善 (P <0 .0 1)。第 6周末治疗组患侧MEP波幅与潜伏期基本恢复正常 ,而对照组患侧MEP波幅仅恢复到 73.5 % ,潜伏期仍有所延长 ,两组相比有显著差异 (P <0 .0 5 )。结论 :经颅电刺激可以促进急性脑梗死大鼠瘫痪肢体运动功能的恢复 ,其机理可能与电刺激直接兴奋大脑皮层的运动中枢有关

Effects of transcranial electrical stimulation on motor funciton recovery after acute cerebral infarction in rats

Objective:To observe the effects of transcranial electrical stimulation on motor function recovery after acute cerebral infarction in experimental rats.Methods:One hundred and twenty adult male SD rats were selected to prepare middle cerebral artery occlusion (MCAO) model, and they were divided into treatment group and control group(each group include 60 rats).Transcranial electrical stimulation was applied to the treatment group,but not to the control. The movement recovery of SD rats after cerebral infarction was evaluated by beam walking test(BWT)and motor evoked potential on the 1st, 2nd, 3rd, 4th, 5th and 6th weekend.Results:The motor function was improved significantly in the treatment group as compared with the control group. The latency and amplitude of MEP recovered to normal on the sixth weekend, but the amplitude of MEP recovered only to 73.5% of the normal level in control group, and the latency of MEP remained to be prolonged. There was significant difference between the two groups. Conclusions:The transcranial electrical stimulation could improve the movement recovery of paralyzed extremities after cerebral infarction. It might be related to the direct exciting effect of transcranial electrical stimulation on the motor center of cerebral cortex.