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| 莲房花青素诱导人肝癌细胞SMMC-7721凋亡的研究 | |
| 引用本文： | 梁慧敏,时小燕,随裕敏,朱斌. 莲房花青素诱导人肝癌细胞SMMC-7721凋亡的研究[J]. 中国实用医药, 2011, 6(19): 37-38 |
| 作者姓名： | 梁慧敏 时小燕 随裕敏 朱斌 |
| 作者单位： | 1. 河南大学淮河临床学院/河南大学淮河医院,1475001 2. 河南大学药学院 3. 岳阳新华达制药有限公司研发中心 |
| 摘 要： | 目的研究莲房花青素对人肝癌细胞株SMMC-7721凋亡的影响,探讨其抗癌机制。方法以不同浓度的莲房花青素(LSPC)与人肝癌细胞株SMMC-7721细胞共培养,MTT法测定细胞增殖。结果 LSPC可体外抑制肝癌细胞生长,抑制率呈浓度和时间依赖性并随浓度增加而增高。结论莲房原花青素(LSPC)可能通过诱导细胞凋亡抑制人肝癌细胞增殖。 |
| 关 键 词： | 莲房原花青素 肝癌细胞 细胞凋亡 |
Effects of proanthocyanidions on apoptosis in SMMC-7721 human hepatocellular carcinoma |
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| LIANG Hui-Min,SHI Xiao-Yan,SUI Yu-Min,et al.. Effects of proanthocyanidions on apoptosis in SMMC-7721 human hepatocellular carcinoma[J]. China Practical Medical, 2011, 6(19): 37-38 | |
| Authors: | LIANG Hui-Min SHI Xiao-Yan SUI Yu-Min et al. |
| Affiliation: | LIANG Hui-Min,SHI Xiao-Yan,SUI Yu-Min,et al. College of Pharmacy,Henan University,KaiFeng 475004,China |
| Abstract: | Objective To investigate the effects of procyanidins from the seedpod of the lotus(LSPC)on apoptosis of human hepatoma cell line SMMC-7721. Methods SMMC-7721 cells were exposed to different concentration of LSPC. The suppression rate of cell proliferation was measured by MTT. Results The cell growth was inhibited significantly by LSPC. Conclusion LSPC inhibits the growth of SMMC-7721 cells and induces apoptosis in a concentration-dependent manner. It is suggested that LSPC has the ability of antitumor by in... |
| Keywords: | Procyanidins from the seedpod of the lotus Hepatocellar carcinoma Apoptosis |
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