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| 两种血细胞分离机干/祖细胞采集和移植效果的比较 | |
| 引用本文： | 叶书来,应美爱,陈家萍,耿良权. 两种血细胞分离机干/祖细胞采集和移植效果的比较[J]. 中国组织工程研究与临床康复, 2011, 15(23). DOI: 10.3969/j.issn.1673-8225.2011.23.039 |
| 作者姓名： | 叶书来 应美爱 陈家萍 耿良权 |
| 作者单位： | 1. 安徽省立医院南区检验科,安徽省合肥市,230001 2. 安徽省立医院输血科,安徽省合肥市,230001 3. 安徽省立医院血液科,安徽省合肥市,230001 |
| 摘 要： | 背景:外周血造血干/祖细胞通过血细胞分离机进行体外收集,血细胞分离机的性能、工作状况将直接关系到采集物的特性和数量,从而直接影响受者的造血重建.目的:比较Fenwal CS-3000 Plus与Amicus两种血细胞分离机采集外周血造血干/祖细胞及受者移植效果.方法:共入选接受异基因外周血干细胞移植患者51例,Fenwal CS-3000 Plus组27例,平均年龄(34.2±10.6)岁;Amicus组24例,平均年龄(35.4±12.1)岁.比较两组采集物有核细胞数、CD34+细胞数、采集效率、红细胞与血小板采集量及造血重建时间.结果与结论:两组采集物的有核细胞数、CD34+细胞数、采集效率、红细胞采集量及造血重建时间差异均无显著性意义;Fenwal CS-3000Plus组血小板采集量明显高于Amicus组(P<0.01).结果显示Fenwal CS-3000 Plus与Amicus血细胞分离机在分离外周血干/祖细胞方面和移植效果没有差异;血小板较低被采集者使用Amicus血细胞分离机采集可能更为安全. |
| 关 键 词： | 血细胞分离机 外周血造血干/祖细胞 CD34+细胞 分离效果 移植 |
Comparison of two blood cell separators in collection of peripheral blood stem cell/progenitor cells and effectiveness of transplantation |
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| Ye Shu-lai,Ying Mei-ai,Chen Jia-ping,Geng Liang-quan. Comparison of two blood cell separators in collection of peripheral blood stem cell/progenitor cells and effectiveness of transplantation[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(23). DOI: 10.3969/j.issn.1673-8225.2011.23.039 | |
| Authors: | Ye Shu-lai Ying Mei-ai Chen Jia-ping Geng Liang-quan |
| Affiliation: | Ye Shu-lai1,Ying Mei-ai2,Chen Jia-ping2,Geng Liang-quan3 1Clinical Laboratory,2Department of Blood Transfusion,3Department of Haematology,Anhui Provincial Hospital,Hefei 230001,Anhui Province,China |
| Abstract: | BACKGROUND:Peripheral blood stem cells/progenitor cells were collected in vitro using blood cell separators,which directly affects the features and quantity of collected cells,additionally,affects hematopoietic reconstitution of recipients.OBJECTIVE:To evaluate the efficiencies of Fenwal CS-3000 Plus and Amicus blood cell separators in collecting peripheral blood stem cells/progenitor cells and effectiveness of transplantation.METHODS:Totally 51 cases received allogenic peripheral blood stem cells transplan... |
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