| 子宫内膜异位症患者内膜细胞中孕激素受体与凋亡因子Bcl-2、Bax表达的研究 |
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| 引用本文： | 王君,李斌,范颖. 子宫内膜异位症患者内膜细胞中孕激素受体与凋亡因子Bcl-2、Bax表达的研究[J]. 实用妇产科杂志, 2010, 26(1) |
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| 作者姓名： | 王君 李斌 范颖 |
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| 作者单位： | 首都医科大学附属北京安贞医院,北京,100029 |
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| 摘 要： | 目的:通过检测孕激素受体(PR)、凋亡抑制基因Bcl-2、促凋亡基因Bax(bcl-associated x protein)在子宫内膜异位症(EMT)中的表达,研究PR与Bcl-2、Bax的关系,探讨EMT的发病机制及选择更有效的药物治疗方案.方法:用免疫组织化学方法及图像分析技术检测PR、Bcl-2、Bax在EMT患者异位及在位内膜细胞中的表达情况.结果:两种检测方法检测结果一致,异位内膜PR、Bcl-2表达低于在位内膜(P<0.05),异位内膜Bax表达高于在位内膜(P<0.05),在位内膜与异位内膜PR、Bcl-2、Bax增殖期与分泌期表达差异无统计学意义(P>0.05).结论:无论是增殖期还是分泌期,EMT中在位内膜PR表达均高于异位内膜及正常内膜,使在位子宫内膜细胞持续低水平增殖,更易于迁徙和种植.在位内膜及异位内膜中Bcl-2和Bax的表达均与子宫内膜周期性改变无关,不受卵巢激素调节,EMT细胞凋亡持续性减弱,增殖性能持续性增强.
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| 关 键 词： | 子宫内膜异位症 孕激素受体 细胞凋亡 |
Expression of PR and Bcl-2,Bax in Ectopic and Eutopic Endometrium in Patients with Endometriosis |
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| WANG Jun,LI Bin,FAN Ying. Expression of PR and Bcl-2,Bax in Ectopic and Eutopic Endometrium in Patients with Endometriosis[J]. Journal of Practical Obstetrics and Gynecology, 2010, 26(1) |
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| Authors: | WANG Jun LI Bin FAN Ying |
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| Affiliation: | WANG Jun,LI Bin,FAN Ying(Beijing Anzhen Hospital of Capital University of Medical Sciences,Beijing 100029,China) |
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| Abstract: | Objective:The pathogenesis of endometriosis(EMT) was explored by detecting the relationship of progesterone receptors(PR) and apoptosis-associated factors with EMT.Methods:Immunohistochemical imaging analysis was used to quantify the expression of PR,Bcl-2 and Bax in ectopic and eutopic endometrium in patients with EMT.Results:Expressions of PR and Bcl-2 in eutopic endometrium are higher than those in ectopic endometrium(P<0.05).Expression of Bax in ectopic endometrium is higher than that in eutopic endomet... |
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| Keywords: | Endometriosis Progesterone receptors Apoptosis |
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