临床药师干预对维持性血液透析患者高磷血症的影响

目的：探讨临床药师参与维持性血液透析患者高磷管理的效果，为提高患者生命质量提供依据。方法： 选择98例进行维持性血液透析的患者，随机分为对照组49例和干预组49例。对照组接受常规的治疗及护理；干预组在此基础上由临床药师对患者进行6个月的高磷管理，分别在3个月和6个月比较两组患者疾病相关知识问卷得分情况、用药依从性，血磷、钙磷乘积、白蛋白、甲状旁腺激素水平。结果：3个月后，干预组在疾病相关知识问卷得分高于对照组（P＜0.05），6个月后，干预组在疾病相关知识问卷、用药依从性得分均高于对照组（P＜0.05）；同时，干预组在6个月后血磷、钙磷乘积、甲状旁腺激素均低于对照组（P＜0.05）。结论：临床药师参与高磷管理可提高血液透析患者的疾病认知度和依从性，降低高磷血症的发生。

Impact of Clinical Pharmacists' Intervention on Hyperphosphatemia in Maintenance Hemodialysis Patients

Objective: To explore the role of clinical pharmacists participating in the management of maintenance hemodialysis patients with high phosphorus and to provide the base for improving life quality of maintenance hemodialysis patients. Methods: Ninety-eight cases under maintenance hemodialysis were selected, which were randomly divided into control and intervention groups. Patients in the control group received conventional treatment and care. Patients in the intervention group received additional management of high phosphorus by clinical pharmacists for 6 months. The scores of disease related knowledge questionnaire, and medication adherence, the serum phosphorus levels, the calcium-phosphorus products and the levels of albumin and parathyroid hormone were evaluated 3 and 6 months after treatments. Results: After 3 and 6 months, the scores of disease related knowledge questionnaire in the intervention group were higher than those in the control group (P<0.05). After 6 months, the scores of medication adherence in the intervention group were higher than those in the control group (P<0.05), meanwhile, the serum phosphorus levels, the calcium-phosphorus products and the parathyroid hormone levels in the intervention group were lower than those in the control group (P<0.05). Conclusion: The management of maintenance hemodialysis patients with high phosphorus by clinical pharmacists improved the knowledge related to the disease and the medication adherence, and decreased the incidence of hyperphosphatemia.