养血清脑颗粒联合尼莫地平治疗颈性眩晕的临床研究

目的 研究养血清脑颗粒联合尼莫地平片治疗颈性眩晕的临床疗效。方法 选取2019年2月-2020年2月天津市第一中心医院收治的100例颈性眩晕患者，将所有患者随机分为对照组和治疗组，每组各50例。对照组患者口服尼莫地平片，1片/次，3次/d。治疗组在对照组基础上口服养血清脑颗粒，1袋/次，3次/d。两组患者持续治疗10 d。观察两组患者临床疗效，比较两组的临床症状缓解时间、椎动脉型颈椎病功能评定量表（FS-CSA）评分、椎动脉血流速度和血清内皮素（ET）、降钙素基因相关肽（CGRP）水平。结果 治疗后，对照组和治疗组的总有效率分别为78.00%、96.00%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组患者眩晕、前庭功能受损、耳蜗症状、自主神经症状消失时间显著短于对照组（P<0.05）。治疗后，两组FS-CSA评分显著降低，椎动脉血流速度显著升高（P<0.05）；并且治疗组FS-CSA评分和椎动脉血流速度改善较明显（P<0.05）。治疗后，两组血清ET水平显著降低，CGRP水平显著升高（P<0.05）；并且治疗组血清ET和CGRP水平改善较明显（P<0.05）。结论 养血清脑颗粒联合尼莫地平片用于治疗颈性眩晕能够缩短临床症状缓解时间，升高椎动脉血流速度，改善患者临床症状和血清ET、CGRP水平。

Clinical study on Yangxue Qingnao Granules combined with nimodipine in treatment of cervical vertigo

Objective To study the clinical effect of Yangxue Qingnao Granules combined with Nimodipine Tablets in treatment of cervical vertigo. Methods Patients (100 cases) with cervical vertigo in Tianjin First Central Hospital from February 2019 to February 2020 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Nimodipine Tablets, 1 tablets/time, three times daily. Patients in the treatment group were po administered with Yangxue Qingnao Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the remission time of clinical symptoms, the FS-CSA score, the blood flow velocity of vertebral artery, and the serum levels of ET and CGRP in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.00% and 96.00%, respectively, and there was significantdifference between two groups (P<0.05). After treatment, the disappearance time of vertigo, vestibular dysfunction, cochlear symptoms, and autonomic nerve symptoms in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the FS-CSA score of the two groups was significantly decreased, but the blood flow velocity of vertebral artery was significantly increased (P<0.05). And the FS-CSA score and the blood flow velocity of vertebral artery in the treatment group were significantly improved more than those in the control group (P<0.05). After treatment, the serum levels of ET and CGRP in two groups were significantly decreased (P<0.05). And the levels of ET and CGRP in the treatment group were significantly better more than those in the control group (P<0.05). Conclusion Yangxue Qingnao Granule combined with Nimodipine Tablets in the treatment of cervical vertigo has good therapeutic effect, can improve the clinical symptoms of patients.