微针与新型经皮给药载体结合的研究进展

经皮给药系统具有给药方便、血药浓度稳定、无首过效应等优点，但皮肤的屏障作用使得药物难以透过皮肤。近年来，出现了很多新型经皮给药的药物载体，如脂质体、醇质体、囊泡等，这些能通过化学方法促进药物的经皮渗透。而微针能穿透皮肤角质层形成微孔通道，通过物理方法促进药物的渗透，将微针与新型经皮给药载体结合能显著提高药物的经皮吸收的速率。本研究对微针与新型经皮给药载体结合的最新研究进行了综述，并展望了微针辅助新型药物载体经皮给药的发展前景。

Research Progress on Combination of Microneedle and New Transdermal Drug Delivery Carrier

ABSTRACT: Transdermal drug delivery system has the advantages of convenient administration, stable blood concentration and no first-pass effect, but the barrier effect of skin makes it difficult for drugs to penetrate the skin. In recent years, a lot of new transdermal drug carriers have emerged, such as liposomes, ethosomes, and vesicles, etc., which can promote the transdermal penetration of drugs through chemical methods. Microneedle can penetrate the skin to form microporous channels and promote the penetration of drugs through physical methods. The combination of microneedle and new transdermal drug carriers can significantly improve the efficiency of drug penetration through the skin. In this paper, the latest research on the combination of microneedle and new transdermal drug delivery vehicles is reviewed, and the development prospect of microneedle assisted new transdermal drug delivery is prospected.