| 发酵支原体MALP-2生物学作用研究进展 |
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| 引用本文： | 梁珂莹,刘君,曾焱华,何军. 发酵支原体MALP-2生物学作用研究进展[J]. 南华大学学报(医学版), 2020, 0(5): 449-453 |
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| 作者姓名： | 梁珂莹 刘君 曾焱华 何军 |
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| 作者单位： | 南华大学附属南华医院检验科,湖南 衡阳 421002;南华大学附属南华医院检验科,湖南 衡阳 421002;南华大学衡阳医学院病原生物学研究所,特殊病原体防控湖南省重点实验室,湖南 衡阳 421001 |
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| 摘 要： | 巨噬细胞活化脂肽-2(MALP-2)是发酵支原体(Mf)上极具代表性的外膜脂肽,N端为特殊的二酰化半胱氨酸残基结构。MALP-2是一把“双刃剑”,在致炎与抗炎、细胞凋亡与抗凋亡、免疫佐剂、生物协同与抑制、血管损伤和血管修复等方面发挥重要作用。因此,了解MALP-2复杂的生物学作用能为理解Mf的致病机制及其临床治疗方案提供依据,同时也为MALP-2的临床应用提供理论基础。
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| 关 键 词： | 发酵支原体 巨噬细胞活化脂肽-2 生物学作用 致病机制 |
| 收稿时间： | 2020-05-07 |
| 修稿时间： | 2020-08-13 |
The progress of immunologic mechanisms of mycoplasma fermentans macrophage-activating lipopeptide-2 |
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| LIANG Keying,LIU Jun,ZENG Yanhu,HE Jun. The progress of immunologic mechanisms of mycoplasma fermentans macrophage-activating lipopeptide-2[J]. Journal of Nanhua University(Medical Edition), 2020, 0(5): 449-453 |
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| Authors: | LIANG Keying LIU Jun ZENG Yanhu HE Jun |
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| Affiliation: | Department of Clinical Laboratory, Nanhua Affiliated Hospital,University of South China, Hengyang 421002, Hunan, China;Department of Clinical Laboratory, Nanhua Affiliated Hospital,University of South China, Hengyang 421002, Hunan, China;Institute of Pathogenic Biology, Hengyang Medical College, University of South China Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang 421001, Hunan, China |
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| Abstract: | Macrophage-activating lipopeptide-2(MALP-2) is a classical mycoplasma-derived outer membrane lipopeptide on Mycoplasma fermentans (Mf) with a special diacylated cysteine residue structure at the N-terminal. MALP-2 poses as a double-edged sword that plays an important role in inflammation and anti-inflammation, apoptosis and anti-apoptosis, immune adjuvant, biological synergy, biological inhibition, vascular injury and vascular repair, etc. Therefore, making out the complex immunologic mechanisms of MALP-2 can provide a basis for understanding the pathogenesis of Mf and its clinical treatment, which also provides a theoretical basis for the clinical application of MALP-2. |
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| Keywords: | mycoplasma fermentans macrophage-activating lipopeptide-2 immuno- logic mechanisms pathogenesis |
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