| CCR2/CCL2对脑缺血再灌注损伤影响的研究进展 |
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| 引用本文： | 贺树成,李运曼,方伟蓉.CCR2/CCL2对脑缺血再灌注损伤影响的研究进展[J].江苏药学与临床研究,2018,26(3):196-201. |
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| 作者姓名： | 贺树成 李运曼 方伟蓉 |
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| 作者单位： | 中国药科大学,中国药科大学,中国药科大学 |
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| 基金项目： | 国家自然科学基金（81673442） |
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| 摘 要： | CC趋化因子受体2（CCR2）是趋化因子受体中的重要一员，与其配体CC趋化因子配体2（CCL2）在神经炎症中发挥着重要的作用。本文综述了CCR2/CCL2的表达及功能，并探讨抑制CCR2/CCL2对脑缺血再灌注损伤的影响及其机制。抑制CCR2/CCL2可降低血脑屏障通透性，并通过影响单核/巨噬细胞、小胶质细胞和星形胶质细胞抑制炎症反应，进而减轻脑缺血再灌注损伤。因此，抑制CCR2/CCL2可能是治疗脑缺血损伤的潜在靶点，为相关药物研发提供依据。
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| 关 键 词： | CCR2 CCL2 脑缺血 血脑屏障 单核/巨噬细胞 小胶质细胞 |
| 收稿时间： | 2018/2/12 0:00:00 |
| 修稿时间： | 2018/3/12 0:00:00 |
Progress on Role of CCR2/CCL2 Signaling in Cerebral Ischemia/Reperfusion Injury |
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| He Shucheng,Li Yunman and Fang Weirong.Progress on Role of CCR2/CCL2 Signaling in Cerebral Ischemia/Reperfusion Injury[J].Jiangsu Pharmacertical and Clinical Research,2018,26(3):196-201. |
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| Authors: | He Shucheng Li Yunman and Fang Weirong |
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| Institution: | China Pharmaceutical University,China Pharmaceutical University,China Pharmaceutical University |
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| Abstract: | CC Chemokine receptor 2 (CCR2), an important member of chemokine receptor, with its ligand CC chemokine ligand 2 (CCL2), plays important roles in neuroinflammation. In this brief review, we summarized current understanding of the expression and functions of CCR2/CCL2. After cerebral ischemia/reperfusion injury, CCR2/CCL2 inhibition could reduce permeability of blood brain barrier, and ameliorate inflammation in brain by affecting monocyte/macrophage, microglia and astrocyte. Therefore, the inhibition of CCR2/CCL2 signaling may be a potential target in treatment of cerebral ischemia, which may benefit the research on medicine for stroke. |
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| Keywords: | CCR2 CCL2 Cerebral Ischemia Blood brain barrier Monocyte/Macrophage Microglia |
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