金莲花软胶囊联合头孢替安治疗儿童急性化脓性扁桃体炎的临床研究

目的 研究金莲花软胶囊联合头孢替安联合治疗儿童急性化脓性扁桃体炎的临床疗效。方法 选择2017年7月-2019年9月在湖北省中医院治疗的急性化脓性扁桃体炎患儿135例，随机分为对照组（67例）和治疗组（68例）。对照组静脉滴注注射用盐酸头孢替安，50 mg/kg，1次/d；治疗组在对照组的基础上口服金莲花软胶囊，2粒/次，3次/d。两组均连续治疗7 d。观察两组患者临床疗效，同时比较治疗前后两组白细胞计数（WBC）、炎性因子白细胞介素-6（IL-6）和C反应蛋白（CRP）水平，及临床症状改善时间。结果 治疗后，对照组和治疗组有效率分别为83.58%和97.06%，两组比较差异有统计学意义（P<0.05）。治疗后，两组WBC、IL-6、CRP均显著下降（P<0.05），且治疗组明显比对照组低（P<0.05）。治疗后，治疗组脓性分泌物消失时间、喉咙痛感消失时间、退热时间均明显比对照组短（P<0.05）。结论 金莲花软胶囊联合头孢替安治疗儿童急性化脓性扁桃体炎，可改善患儿临床症状，缓解患儿机体炎症反应，临床效果较好，安全可靠。

Clinical study on Jinlianhua Soft Capsules combined with cefotiam in treatment of acute tonsillitis in children

Objective To observe the clinical effect of Jinlianhua Soft Capsules combined with cefotiam in treatment of acute tonsillitis in children. Methods Children (135 cases) with acute tonsillitis in Hubei Hospital of Traditional Chinese Medicine from July 2017 to September 2019 were randomly divided into control (67 cases) and treatment (68 cases) groups. Children in the control group were iv administered with Cefotiam Hydrochloride for injection, 50 mg/kg, once daily. Children in the treatment group were po administered with Jinlianhua Soft Capsules on the basis of the control group, 2 grains/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the WBC, the inflammatory factor levels of IL-6 and CRP, the improvement time of clinical symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 83.58% and 97.06%, respectively, and there were differences between two groups (P<0.05). After treatment, the WBC, the inflammatory factor levels of IL-6 and CRP in two groups were significantly decreased (P<0.05), and these indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the disappearance time of purulent secretion, sore throat, and antipyretic time in the treatment group was significantly shorter than that in the control group (P<0.05). Conclusion Jinlianhua Soft Capsules combined with cefotiam in treatment of acute tonsillitis in children can rapidly improve clinical symptoms, and relieve the inflammatory response, which has good clinical effect with safety and reliability.