Effect of annexin-A1 peptide treatment during lung inflammation induced by lipopolysaccharide |
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| Authors: | da Cunha Esther Emanuella Oliani Sonia Maria Damazo Amílcar Sabino |
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| Institution: | 1. Department of Biology, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (UNESP), 15054-000 São José do Rio Preto, SP, Brazil;2. Department of Basic Science in Health, Faculty of Medicine (FM), Federal University of Mato Grosso (UFMT), 78060-900 Mato Grosso, MT, Brazil;1. Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District Huimin Road No. 211, Chengdu 611130, China;2. Department of Aquaculture, Sichuan Province Bureau of Aquatic Products, Chenghua District Donghong Road No. 60, Chengdu 610072, China;3. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang District Huimin Road No. 211, Chengdu 611130, China;4. Department of Aquaculture, Sichuan Agricultural University, Wenjiang District Huimin Road No. 211, Chengdu 611130, China;1. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, United States;2. Institute for Behavioral Medicine Research, Wexner Medical Center at The Ohio State University, Columbus, OH 43210, United States;3. Joy McCann Culverhouse Airway Disease Research Center, Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, United States;2. Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Huazhong University of Science and Technology, Wuhan 430030, People''s Republic of China;1. Department of Ophthalmology, Albany Medical College, Albany, New York;2. Albany Medical College, Albany, New York;3. Glaucoma Consultants of the Capital Region in Slingerlands, New York |
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| Abstract: | Lung endotoxemia is characterized by neutrophil accumulation, increased vascular permeability and parenchymal injury. This can also affect the endogenous pathways that operate in the host to keep inflammation under control. Here, we demonstrate differential expression of annexin-A1 (AnxA1) protein in mice after the local or intraperitoneal administration of lipopolysaccharide (LPS; 1 mg/kg) in mice and the regulation of the endotoxemic inflammation after the pre-treatment with the AnxA1 peptidomimetic Ac2-26. The intranasal administration of LPS induced the leukocyte migration and cytokine release to the alveolar space, whereas the peritoneal administration of LPS generated a deregulated cellular and cytokine response, with a marked degree of leukocyte adhesion in the microcirculation. The peptide Ac2-26 pre-treatment inhibited the leukocyte migration and the pro-inflammatory cytokine release. Also, it induced the expression of endogenous AnxA1 and the anti-inflammatory cytokine IL-10. In conclusion, our data obtained from endotoxemia induced by local or intraperitoneal LPS administration suggested that the molecular mechanisms induced by AnxA1 peptidomimetic Ac2-26 lead to the regulation of leukocyte activation/migration and cytokine production induced by LPS. |
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