白介素-10与白介素-12在支气管哮喘发病中的作用

目的　探讨IL 10和IL 12在支气管哮喘发病中的作用。方法　采用酶联免疫法测定不同时期支气管哮喘患者血清IL 10、IL 12和IgE水平,并与正常对照组进行统计分析。结果　发作期支气管哮喘患者血清 IL 10和 IL 12水平显著低于缓解期和正常对照组(P<0.01),而IgE水平却显著高于缓解期和正常对照组 (P<0.01)。发作期支气管哮喘患者血清 IL 10、IL 12与IgE之间存在负相关 (r=-0.73,r=-0.69,P<0.01 ),而IL 10与IL 12之间呈正相关 (r=0.82,P<0.01 )。结论　IL 10和IL 12在支气管哮喘发病中发挥着网络效应,起着重要的调节作用。

The role of serum IL-10 and IL-12 in patients with asthma

Objective To study the role of serum IL -10 and IL-12 in patients with asthma.Methods The serum levels of IL-10, IL-12 and IgE were measured by ELISA in 38 cases of asthma at stage of episode and 33 cases of asthma at stage of remission and 30 healthy people. Results The levels of IL-10 and IL-12 in the attacking-stage asthma were 11.7±4.6pg/mland 85.3±22.9pg/ml, respectively, which significantly lower than those of remission patients( 16.0±6.1pg/ml, 138.0±40.7pg/ml) and normal controls (19.2±7.3pg/ml, 189.7±71.8pg/ml)(P<0.01).The level of IgE was 370.3±107.1IU/ml in attacking-stage asthma, which was significantly higher than that of the remission patients(218.1±41.2IU/ml )and the normal controls(89.4±26.IU/ml)(P<0.01). It is suggested that IL-10 and IL-12 has negative correlation with IgE(r=-0.73, r=-0.69, P<0.01 ,and IL-10 has positive correlation with IL-12(r=0.82)(P<0.01).Conclusion IL-10 and IL-12 play crucial roles of regulation in the onset and developing of asthma.