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HIV/AIDS-related cardiovascular disease |
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| Authors: | Alysia A. Chaves Michael J. Mihm Anupam Basuray Reshma Baliga Leona W. Ayers John A. Bauer PhD |
| Affiliation: | (1) Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Children’s Hospital, 700 Columbus Drive, 43205 Columbus, OH;(2) Department of Pathology/College of Medicine, The Ohio State University, Columbus, OH;(3) Division of Pharmacology/College of Pharmacy, The Ohio State University, 700 Columbus Drive, 43205 Columbus, OH;(4) Department of Pediatrics/College of Medicine, The Ohio State University, Columbus, OH |
| Abstract: | Recent advances in antiretroviral therapies have enhanced survival of HIV/AAIDS patients, but cardiovascular complications have emerged as important issues in this growing patient population. Although the antiviral drug therapies apparently yield cardiac and/or vascular toxicities themselves, several other factors associated with HIV pathogenesis have also been implicated. This brief review provides an overview of the significance and complexities of HIV/AIDS-related cardiovascular complications and ad resses some important mechanistic aspects that may contribute to this important clinical problem. |
| Keywords: | HIV cardiovascular oxidants co-infectious pathogens |
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