Sesquiterpene esters of aristolochic acid from the root and stem of Aristolochia heterophylla |
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| Authors: | Wu T S Chan Y Y Leu Y L Chen Z T |
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| Institution: | Department of Chemistry, National Cheng Kung University, Tainan, Taiwan 701, Republic of China. tswu@mail.ncku.edu.tw |
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| Abstract: | Three novel sesquiterpene esters of aristolochic acid, aristoloterpenate-II (2), -III (3), and-IV (4), together with known aristoloterpenate-I (1), were isolated and characterized from the root and stem of Aristolochia heterophylla. Their structures were elucidated by spectroscopic methods. The absolute configuration of these compounds at C-4' was determined as R by circular dichroic studies. These compounds showed cytotoxicity against hepatoma G2, 2, 2, 15 cells. |
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