帕米膦酸二钠的合成

目的：合成二钠３－氨基－１－羟基－亚丙基－二膦酸盐（帕米膦酸二钠）。方法：有，无溶剂的两种合成路线，并对工艺进行改进，所得产物经元素分析，红外光谱，质谱等分析确证结构。结果；两种路线均可合成目标化合物。路线Ａ收率高于路线Ｂ。结论：溶剂的加入使本反应体系均一，有利于产物生成。

Synthesis of disodium 3-amino-1-hydroxy-propilidene-1,1-diphosphonate

OBJECTIVE:To synthesize disodium 3-amino-1-hydroxy-propilidene-1,1-diphosphonate.METHOD:Two processes had been improved(with or within solvent).Chemical structures of products were confirmed by element analysis,IR,MS,et al.RESULTS:Both of the two processes can obtain the target molecular.Yield of path A is higher than that of path B.CONCLUSION:Solvent homogenized the reaction system,and was beneficial for the reaction.