| PTEN、VEGF在胃癌组织中表达的相关性 |
| |
| 引用本文： | 周素英,骆利康,申华峰,徐文兴,邵海燕.PTEN、VEGF在胃癌组织中表达的相关性[J].肿瘤学杂志,2008,14(4):264-266. |
| |
| 作者姓名： | 周素英 骆利康 申华峰 徐文兴 邵海燕 |
| |
| 作者单位： | 衢州市人民医院,浙江,衢州,324000 |
| |
| 摘 要： | 目的]探讨胃癌组织中PTEN和VEGF的表达及相互关系。方法]应用免疫组化EnVision法检测65例胃癌组织中PTEN和VEGF的表达。结果]胃癌组织中PTEN高表达率和VEGF阳性表达率分别为43．1％（28／65）和60．0％（39／65），与肿瘤的分化程度、浸润深度、淋巴结转移显著相关（P〈0．05）；Spearman等级相关分析显示PTEN与VEGF表达显著负相关（r=-0．368，P〈0．05）。结论]胃癌组织中PTEN表达减少，VEGF表达增高，PTEN可能通过调控胃癌组织中的VEGF来抑制血管生成,从而抑制肿瘤的浸润和转移,影响病人的预后。
|
| 关 键 词： | 胃肿瘤 PTEN VEGF 预后 |
| 文章编号： | 1671-170X(2008)04-0264-03 |
| 修稿时间： | 2007年7月31日 |
Correlation of Expressions Between PTEN and VEGF in Gastric Cancer |
| |
| Institution: | ZHOU Su-ying, LUO Li-kang, SHEN Hua-feng, et al. (Quzhou People＇s Hospital, Quzhou 324000, China) |
| |
| Abstract: | Purpose] To investigate expression of PTEN and VEGF in human gastric carcinoma and their correlation. Methods] Expression of PTEN and VEGF was examined by EnVision method immunohistochemically in 65 cases with gastric carcinoma. Results] High expression of PTEN and positive expression of VEGF was 43.1% （28/65） and 60.0%（39/65）, respectively in gastric can- cer, which significantly correlated with tumor differentiation, depth of tumor invasion and lymph node metastasis（P〈0.05）. Expression of PTEN negatively correlated with VEGF（r=-0.368,P〈0.05）. Conclulsion] Expression of PTEN decreases and expression of VEGF increases in gastic carcinoma. PTEN could inhibit tumor angiogenesis through regulating expression of VEGF, to suppress tumor invasion and metastasis. |
| |
| Keywords: | gastric neoplasms PTEN VEGF prognosis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
