Favorable outcome of chronic disseminated candidiasis in four pediatric patients with hematological malignancies |
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Authors: | Donker Albertine E Mavinkurve-Groothuis Annelies M C van Die Lya E Verweij Paul E Hoogerbrugge Peter M Warris Adilia |
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Institution: | Department of Pediatric Hematology and Oncology, Harbor Hospital, Rotterdam, the Netherlands. a.donker@cukz.umcn.nl |
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Abstract: | Four children were diagnosed with chronic disseminated candidiasis (CDC) during treatment for hematological malignancies. All presented with persistent fever, not responsive to broad-spectrum antibiotics, abdominal distension and hepatosplenomegaly. Two children needed artificial ventilation because of respiratory insufficiency. The time between onset of neutropenic fever and diagnosis of CDC ranged from 20-49 days. Ultrasound and computed tomography failed to demonstrate CDC during the neutropenic phase. All children needed a liver or spleen biopsy to establish the diagnosis of CDC. Three of four patients continued chemotherapy during treatment for the fungal infection. All patients had a favorable outcome, both in terms of the invasive Candida infections, as well as their underlying malignancies. |
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