|
|||||
|
|
BCL6 overexpression is associated with decreased p19ARF expression and confers an independent prognosticator in gallbladder carcinoma |
|
| Authors: | Peir-In Liang Chien-Feng Li Li-Tzong Chen Ding-Ping Sun Tzu-Ju Chen Chung-Hsi Hsing Han-Ping Hsu Ching-Yih Lin |
| Institution: | 1. Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100, Tzyou 1st Rd, Kaohsiung 807, Taiwan 2. Department of Pathology, Chi-Mei Foundation Medical Center, 901, Zhonghua Rd., Yongkang Dist, Tainan City 710, Taiwan 3. National Institute of Cancer Research, National Health Research Institutes, 367 Shengli Rd, Tainan City 704, Taiwan 4. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 100, Tzyou 1st Rd, Kaohsiung 807, Taiwan 5. Department of Biotechnology, Southern Taiwan University of Science and Technology, 1, Nan-Tai Street, Yongkang Dist, Tainan City 710, Taiwan 6. Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 100, Tzyou 1st Rd, Kaohsiung 807, Taiwan 7. Division of General Surgery, Department of Surgery, Chi-Mei Medical Center, 901, Zhonghua Rd., Yongkang Dist, Tainan City 710, Taiwan 8. Department of Anesthesiology, Chi-Mei Medical Center, 901, Zhonghua Rd., Yongkang Dist, Tainan City 710, Taiwan 9. College of Medicine, Taipei Medical University, 250, Wu-Hsing Street, Taipei City 110, Taiwan 10. College of Medicine, China Medical University, 91, Hsueh-Shih Road, Taichung City 404, Taiwan 11. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Foundation Medical Center, 901, Zhonghua Rd., Yongkang Dist, Tainan City 710, Taiwan 12. Department of Leisure, Recreation, and Tourism Management, Southern Taiwan University of Science and Technology, 1, Nan-Tai Street, Yongkang Dist, Tainan City 710, Taiwan |
| Abstract: | B cell lymphoma 6 (BCL6) is a protein that is vital for lymphogenesis. Its expression has been well established in lymphoma, especially in diffuse large B-cell lymphoma. Its role in carcinogenesis is less well understood. Previous study shows that BCL6 expression may regulate p19 functions, an important regulator for the p53 pathway. No prior study has attempted to evaluate the significance of BCL6 and p19ARF expression in a large cohort of patients with gallbladder carcinomas (GBCs). We selected 164 patients with GBC and performed immunostains for BCL6 and p19ARF. BCL6 expression and p19ARF expression were evaluated using a histochemical score (H-score). We then correlated the results with various clinicopathological factors, disease-specific survival (DSS), and disease-free survival (DFS). BCL6 overexpression was significantly associated with high pT status, high TNM stage, higher histological grade (p?=?0.029), vascular invasion, perineurial invasion, high Ki-67 labeling index, and low p19 expression. Importantly, BCL6 overexpression in GBC was strongly associated with worse DSS (p?<?0.0001) and DFS (p?<?0.0001) in the univariate analysis, and remained independently predictive of adverse outcomes (p?=?0.001, hazard ratio (H.R.)?=?3.098 for DSS; p?=?0.002, H.R.?=?2.255 for DFS). Low p19ARF expression was correlated with a poor DSS (p?=?0.0144) and DFS (p?=?0.0032) in the univariate analysis but was not prognosticatory in the multivariate analysis. In GBC, BCL6 overexpression correlated with adverse phenotypes and decreased p19ARF expression. BCL6 overexpression also independently predicts worse DSS and DFS, suggesting it has a role in tumorigenesis or carcinogenesis and could be a potential prognostic indicator in GBC. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |