肺癌患者介入治疗前后凝血、纤溶及血小板功能的变化

目的研究原发性支气管肺癌介入治疗前（A1组）、后（A2组）凝血及纤溶功能的变化。方法比较A1组（52例）、A2组（52例）及30例对照组（B组）指标。PT、aPTT、TF、Fbg、FⅦ、FⅧ、FX采用光散射比浊法，P-选择素（Ps），血管性血友病因子（vWF），尿激酶型纤溶酶原激活物（uPA）采用ELISA法，uPA抑制物（PAI）采用发色底物法测定。结果1．与B组比较，A1组aPTT、TT、Fbg、FⅧ、Ps、vWF、uPA和PAI均升高（P〈0．05～0.01）。2．与A1组比较，A2组Fbg、FⅦ、Ps、uPA和PAI降低（P〈0．05～0．01）。结论原发性支气管肺癌患者凝血及纤溶过度激活，血小板活化，介入治疗后减轻。

Alternation of Blood Coagulation,Fibrinolytic and Platelet Function Before and After the Interventional Therapy of Primary Pulmonary Carcinoma

Objective To terventional therapy of primary study the changes of blood coagulation and fibrinolytic function before the inpulmonary carcinama （group A1 ） and after that （ group A2） . Methods To analyze PT, aPTT, TF, Fbg, F Ⅶ, F Ⅷ, F X in group A1 （ n = 52 ）, group A2 （ n = 52 ） and control group （group B n = 30） with the light scattering turbidimetry, and P-selectin （Ps）, you Willebrand factor （vWF）, urokinase profibrinolytic activating factor （uPA） were examined by ELISA, and uPA＇ s inhibitor （PAl） with chromogenic substracte. Results aPTT , TT,Fbg,FⅧ,Ps,vWF,uPA and PAl in group A1 were higher than those in group B（P 〈0.05 -0.01 ）. Fg,FⅧ,Ps,uPA and PAI in group A2 were less than those in group A1 （ P 〈 0.05 - 0.01 ）. Conclusion The blood coagulation and fibrinolytic function of primary pulmonary carcinoma were over activated, platelet was animated, and abated after interventional therapy