| 1,6-二磷酸果糖的体内过程研究 |
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| 引用本文： | 肖华凤,杨敏,潘尚仁,冯英英.1,6-二磷酸果糖的体内过程研究[J].中国医药导报,2007,4(2):42-44. |
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| 作者姓名： | 肖华凤 杨敏 潘尚仁 冯英英 |
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| 作者单位： | 1. 西南民族大学校医院,成都,610041
2. 江苏省原子医学研究所,江苏无锡,214063 |
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| 摘 要： | 目的:研究1,6-二磷酸果糖的体内过程。方法:取SD大鼠,静脉注射三种剂量的32P]FDP,考察其在大鼠体内吸收、分布、代谢、排泄过程。结果:三种剂量给药后的药物动力学显示血浆半衰期约为10min,表观分布容积与体重相当。心、肝、肾、脾和肺的放射性浓度高,肌肉和脂肪中的浓度低。给药后第1天约通过尿排泄10%。结论:32P]FDP静脉注射后迅速随血流分布,心中浓聚,此研究为其治疗心血管、慢性阻塞性肺病(COPD)等疾病提供临床理论依据。
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| 关 键 词： | 1 6-二磷酸果糖 药物动力学 药理学 毒理学 |
| 文章编号： | 1673-7210(2007)01(b)-042-03 |
| 修稿时间： | 2006年12月8日 |
The fate of fructose 1,6-diphosphate |
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| XIAO Huafeng,YANG Min,PAN Shangren,FENG Yingying.The fate of fructose 1,6-diphosphate[J].China Medical Herald,2007,4(2):42-44. |
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| Authors: | XIAO Huafeng YANG Min PAN Shangren FENG Yingying |
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| Abstract: | Objective:To study the fate of 32P]-Fructose 1,6-diphosphate(FDP) in rats.Methods:32P labeled FDP was prepared. The absorption, biodistribution and excretion of the SD rats were measured at different times after intravenous injecting 32P]- FDP.Results:The pharmacokinetics by three dosages indicated that the half lives were 10 min and the apparent volume of distribution was analogous to the body.The radioactivity was higher in liver , kidney , heart , spleen and lower in brain and fat .It was excreted 10% in urine within first day after IV injection.Conclusion:After iv injection,32P]- FDP is rapidly distributed to the tisssues by blood, especially high accumulation in the heart. This study provide the basis for the clinic use of FDP. |
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| Keywords: | FDP Pharmacokinetics Pharmacology Metabolism |
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