宫颈鳞癌PTEN和P-ERK的表达及其临床意义

目的:探讨PTEN和P-ERK子宫颈鳞癌组织中的表达及临床意义。方法:采用免疫组化SP法观察114例宫颈鳞癌组织和50例宫颈正常组织石蜡标本中PTEN蛋白和P-ERK蛋白的表达情况。结果:宫颈鳞癌组织中PTEN蛋白阳性表达率(61.4%)明显低于正常宫颈组织(100%)(P<0.05);P-ERK蛋白在子宫颈鳞癌中的阳性表达率(84.2%)明显高于正常宫颈组织(16.0%)(P<0.05);子宫颈鳞癌中PTEN和P-ERK蛋白表达之间呈明显的负相关(P<0.01)。结论:PTEN蛋白的低表达或失表达,不能有效抑制Ras/Raf/MEK/ERK信号通路的异常激活,使细胞恶性转化和增殖。

Expression of PTEN and P-ERK protein in cervical squamous cell carcinoma and its clinical significance

Objective:To investigate the expression of PTEN and P-ERK protein in cervical squamous cell carcinoma and its clinical significance.Methods:Expression of PTEN and P-ERK protein was detected in 114 specimens of cervical squamous cell carcinoma and 50 specimens of normal tissues using SP immunohistochemistry.Results:The positive rate of PTEN protein was significantly lower in cervical squamous cell carcinoma( 61.4%)than that in normal tissues (100%) (P<0.05);The positive rate of P-ERK was significantly higher in cervical squamous cell carcinoma (84.2%) than that in normal tissues (16.0%) (P<0.05);A significant negative relationship was observed between the expression of PTEN and P-ERK protein in cervical squamous cell carcinoma (P<0.01).Conclusion:The decrease or deletion of PTEN protein expression may not able to effectively inhibit the over-activation of Ras/Raf/MEK/ERK signaling pathway,which will result in the malignant transformation and proliferation.