慢性丙型肝炎患者血清视黄醇结合蛋白4水平及相关影响因素的研究

目的 探讨慢性丙型肝炎患者血清视黄醇结合蛋白4(RBP4)的水平及相关影响因素.方法 选择56例慢性丙型肝炎患者(观察组)及35例健康体检者(对照组),采用ELISA法测定空腹血清RBP4水平,并测定空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、丙氨酸氨基转移酶(ALT)、γ谷氨酰转移酶(γ-GT),PCR法测定丙型肝炎病毒(HCV)-RNA水平.结果 两组FBG、TC、TG、γ-GT水平比较差异无统计学意义(P＞0.05),观察组血清RBP4水平为(33.38±6.43)mg/L,明显高于对照组的(26.11±3.35)mg/L(P＜0.01).ALT正常的观察组26例患者血清RBP4水平为(38.96±4.09)mg/L,明显高于ALT异常的观察组30例患者的(28.53±3.43)mg/L(P＜0.01).观察组患者的ALT水平与RBP4水平呈负相关(r=-0.6368,P＜0.05).结论 血清RBP4水平与慢性丙型肝炎有显著相关性,且与ALT呈负相关,与FBG、TC、TG、γ-GT及HCV-RNA无关.

The study of serum retinol-binding protein 4 and related factors in chronic hepatitis C

Objective To investigate the level of serum retinol-binding protein 4 (RBP4) and related factors in chronic hepatitis C (CHC). Methods Fifty-six patients with CHC (CHC group) and 35 healthy volunteers (control group) were selected. Serum RBP4 level was measured by ELISA method.Fasting blood glucose ( FBG ), triglycerides (TG), total cholesterol ( TC ), alanine aminotransferase (ALT),γ-glutamyl transpeptidase (γ-GT) were measured, HCV-RNA level was tested by qualitative polymerase chain reaction(q-PCR). Results There were no significant difference in FBG, TC,TG, γ-GT between two groups (P ＞ 0.05 ). Serum RBP4 level in CHC group [(33.38 ± 6.43 ) mg/L] was higher than that in control group [(26.11 ± 3.35) mg/L](P＜ 0.01),the CHC patients with ALT normal (26 cases) had significantly higher RBP4 level [( 38.96 ± 4.09) mg/L] compared with ALT abnormal [30 cases, ( 28.53 ± 3.43 ) mg/L](P ＜ 0.01 ). ALT level was negative with RBP4 in CHC group (r = -0.6368, P ＜ 0.05 ). Conclusion Serum RBP4 level is significantly associated with CHC and negatively correlated with ALT level,but not associated with FBG, TC,TG, γ-GT and HCV-RNA.