前列地尔治疗急性百草枯中毒肺损伤的疗效分析

目的分析前列地尔治疗急性百草枯中毒(PQ)肺损伤的疗效。方法将30例百草枯中毒患者随机分组分为治疗组15例和对照组15例,所有患者均接受序贯性血液净化(血浆置换+血液灌流+血液透析)联合综合治疗。对照组静脉注射甲泼尼龙;治疗组在对照组治疗基础上加用前列地尔。结果对照组40%患者有效,治疗组75%患者有效,两组间有效比例差异有统计学意义(P<0.05)。治疗组治疗后PaO2、PaCO2、PaO2/FiO2改善较对照组显著(P<0.05)。治疗组治疗后X线胸片提示肺损伤好转9例,显著多于对照组5例(P<0.05);死亡率两组无差异。结论前列地尔注射液可以显著改善动脉血气、呼吸参数,对急性PQ中毒肺损伤有积极的治疗作用。

Treatment of Pulmonary Damage in Acute Paraquat Poisoning with Alprostadil:Clinical Observation of 15 Cases

Objective To analyze the efficacy of alprostadil for treatment of pulmonary damage in acute paraquat poisoning.Methods 30 patients with paraquat poisoning were randomly divided into treatment group(n=15) and control group(n=15),all patients underwent sequential blood purification(plasma exchange + hemoperfusion + hemodialysis) combined with comprehensive treatment.The control group was intravenously infused methylprednisolone;the treatment group was treated based on the use of alprostadil.Results In the control group 40% patients were effective,in the treatment group 75% patients were effective,the effective ratio between the two groups was significant(P <0.05).After treatment,PaO2,PaCO2,PaO2/FiO2 improved significantly than the control group(P <0.05).After treatment,X-ray prompted improvement in 9 patients with acute pulmonary damage,which were significantly more than the control group(n=5,P <0.05);there was no difference in mortality.Conclusion Alprostadil injection can significantly improve arterial blood gas,respiratory parameters,which has a positive therapeutic effect on pulmonary damage in acute paraquat poisoning.