| 骨髓单个核细胞移植对小鼠酒精性肝纤维化的影响 |
| |
| 引用本文： | 廖彩佶,廖彩仙,廖欣鑫,赖勇强,龚祖元. 骨髓单个核细胞移植对小鼠酒精性肝纤维化的影响[J]. 医疗保健器具, 2011, 18(1): 13-14. DOI: 10.3936/j.issn.1674-4659.2011.01.0013 |
| |
| 作者姓名： | 廖彩佶 廖彩仙 廖欣鑫 赖勇强 龚祖元 |
| |
| 作者单位： | 1. 广州市白云区红十字会医院外一科,广东广州,510545
2. 南方医科大学南方医院肝胆外科,广东广州,510515 |
| |
| 摘 要： | 目的探讨骨髓源性肝干细胞移植对小鼠肝纤维化的影响。方法16只酒精性肝纤维化雌性小鼠随机分为移植组和对照组，移植组小鼠（n=8）接受同基因型雄性小鼠的骨髓单个核细胞移植，对照组小鼠（n=8）接受等体积的含10％小牛血清IMDM培养液输注。术后30天活杀小鼠取血行肝功能测定、取肝行常规组织病理学观察和肝组织中胶原含量测定。结果移植组小鼠的肝功能和肝结构恢复显著优于对照组，肝组织中的胶原含量显著少于对照组。结论骨髓源性肝干细胞移植可以使小鼠肝纤维化病变的结构和功能得到显著改善，可以显著减少纤维化肝组织中的胶原含量。
|
| 关 键 词： | 骨髓 肝干细胞 移植 小鼠 肝纤维化 |
The Action of Bone Marrow Mononuclearcell Transplantation on Alcoholic Liver Fibrosis in Mice |
| |
| LIAO Caiji,LIAO Caixian,LIAO Xinxin,LAIO Yongqiang,GONG Zuyuan. The Action of Bone Marrow Mononuclearcell Transplantation on Alcoholic Liver Fibrosis in Mice[J]. Medicine Healthcare Apparatus, 2011, 18(1): 13-14. DOI: 10.3936/j.issn.1674-4659.2011.01.0013 |
| |
| Authors: | LIAO Caiji LIAO Caixian LIAO Xinxin LAIO Yongqiang GONG Zuyuan |
| |
| Affiliation: | LIAO Caiji1,LIAO Caixian2,LIAO Xinxin2,LAI Yongqiang2,GONG Zuyuan2(1Department of Surgery One,Red Cross Hospital of Baiyun District of Guangzhou,Guangzhou 510545,China,2Department of Hepatobiliary Surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China) |
| |
| Abstract: | Objective To explore the action of bone marrow mononuclearcell transplantation on hepatic fibrosis in mice.Method 16 female mice with alcoholic liver fibrosis were randomly divided into group A(n = 8) and B(n =8).The mice in group A received syngeneic male mice bone marrow mononuclearcell transplantation.The animals in group B received isovolumetric IMDM supplemented with 10% new bovine serum infusion.The examinations of hepatic function,hepatic histopathology and collagen content in hepatic tissue were per... |
| |
| Keywords: | Bone marrow Mononuclearcell Transplantation Mouse Alcoholic liver fibrosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
